Detorakis Efstathios T, Koukoula Stavrenia, Chrisohoou Fotios, Konstas Anastasios G, Kozobolis Vassilios P
Department of Ophthalmology, Democritus University of Thrace, Thrace, Greece.
Cornea. 2005 Aug;24(6):688-91. doi: 10.1097/01.ico.0000154232.18618.e0.
Corneal involvement and disturbances of the tear film have been reported in pseudoexfoliation syndrome (PEX). Tear film deficiencies are correlated with changes in corneal sensitivity. The present study aims at evaluating central corneal mechanical sensitivity (CCMS) in PEX.
Patients with unilateral or bilateral PEX findings constituted the study group (SG). Age- and gender-matched patients without PEX in either eye constituted the control group (CG). Patients with conditions affecting corneal sensitivity were excluded. CCMS and central corneal thickness (CCT) were measured (using a Cochet-Bonnet esthesiometer and an ultrasonic pachymeter, respectively). Schirmer (ST) and break-up time (BUT) tests were also performed.
The SG included 40 patients (24 male, 60%). The CG included 38 patients (25 male, 65.78%). ST scores were significantly lower in the SG compared with the CG (11.45 +/- 2.52 mm and 14.27 +/- 1.18 mm, respectively, P = 0.04). BUT scores were also significantly lower in the SG compared with the CG (7.64 +/- 2.37 mm and 12.43 +/- 3.14 mm, respectively, P = 0.03). CCMS was significantly (P = 0.02) reduced in the SG compared with CG (4.54 +/- 0.23 cm and 5.73 +/- 0.44 cm, respectively). Differences in CCT between the SG and the CG were not statistically significant.
The decrease in CCMS in PEX eyes may be related to decreased BUT and ST scores in PEX, as previously described. However, a direct involvement of sensory nerves may also participate. The reduction in CCMS may have implications for the clinical management of PEX patients.
已有报道称，假性剥脱综合征（PEX）存在角膜受累及泪膜紊乱的情况。泪膜缺陷与角膜敏感性变化相关。本研究旨在评估PEX患者的中央角膜机械敏感性（CCMS）。
有单侧或双侧PEX表现的患者组成研究组（SG）。年龄和性别匹配、双眼均无PEX的患者组成对照组（CG）。排除影响角膜敏感性的疾病患者。分别使用科谢 - 博内测痛仪和超声测厚仪测量CCMS和中央角膜厚度（CCT）。还进行了泪液分泌试验（ST）和泪膜破裂时间（BUT）测试。
SG组包括40例患者（24例男性，占60%）。CG组包括38例患者（25例男性，占65.78%）。与CG组相比，SG组的ST评分显著更低（分别为11.45±2.52毫米和14.27±1.18毫米，P = 0.04）。与CG组相比，SG组的BUT评分也显著更低（分别为7.64±2.37毫米和12.43±3.14毫米，P = 0.03）。与CG组相比，SG组的CCMS显著降低（P = 0.02）（分别为4.54±0.23厘米和5.73±0.44厘米）。SG组和CG组之间的CCT差异无统计学意义。
如前所述，PEX患眼中CCMS的降低可能与PEX中BUT和ST评分降低有关。然而，感觉神经的直接受累也可能起作用。CCMS的降低可能对PEX患者的临床管理有影响。
