Woldringh Conrad L
Section Molecular Cytology, Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Kruislaan 316, 1098 SM Amsterdam, The Netherlands.
Bioessays. 2005 Aug;27(8):770-4. doi: 10.1002/bies.20271.
Whether or not bacteria divide symmetrically, the inheritance of cell poles is always asymmetrical. Because each cell carries an old and a new pole, its daughters will not be the same. Tracking poles of cells and measuring their lengths and doubling times in micro-colonies, Stewart et al.1 observed that growth rate diminished in cells inheriting old poles and concluded that these cells are susceptible to aging. Here, their results are compared with studies on the variabilities of length and age at division. It is argued that the decreased growth rate in old pole cells falls within the expected variation and may therefore be sufficiently far from a catastrophe-like cell death through aging.
无论细菌是否对称分裂，细胞极的遗传总是不对称的。由于每个细胞都有一个旧极和一个新极，其后代细胞并不相同。通过追踪细胞的极并测量它们在微菌落中的长度和倍增时间，斯图尔特等人观察到继承旧极的细胞生长速率下降，并得出结论认为这些细胞易于衰老。在此，将他们的结果与关于细胞分裂时长度和年龄变异性的研究进行比较。有人认为，旧极细胞中生长速率的下降处于预期的变异范围内，因此可能与因衰老导致的类似灾难的细胞死亡相距甚远。
