Wolff M, Chavanet P, Kazmierczak A, Pechinot A, Dematons C, Portier H, Lenfant B
Clinique de Réanimation des Maladies Infectieuses, Hôpital Bichat-Claude Bernard, Paris, France.
J Antimicrob Chemother. 1992 Apr;29 Suppl A:59-62. doi: 10.1093/jac/29.suppl_a.59.
We evaluated the diffusion of cefpirome into the cerebrospinal fluid (CSF) of 25 patients with bacterial meningitis or ventriculitis who were receiving conventional antibiotic treatment. A single cefpirome dose of 2 g was infused at day 2-3 after the onset of therapy. Concentrations of cefpirome in serum and CSF obtained at 2, 4, 8 or 12 h after the infusion were determined by high-performance liquid chromatography. The mean (+/- S.E.M.) concentrations of cefpirome in CSF ranged from 2.26 +/- 1.16 to 4.17 +/- 0.83 mg/L. These concentrations were higher than the MBCs for the pathogens usually responsible for bacterial meningitis.
我们评估了头孢匹罗在25例接受传统抗生素治疗的细菌性脑膜炎或脑室炎患者脑脊液（CSF）中的扩散情况。在治疗开始后的第2 - 3天静脉输注2 g单剂量头孢匹罗。输注后2、4、8或12小时采集的血清和脑脊液中头孢匹罗的浓度通过高效液相色谱法测定。脑脊液中头孢匹罗的平均（±标准误）浓度范围为2.26±1.16至4.17±0.83 mg/L。这些浓度高于通常引起细菌性脑膜炎的病原体的最低杀菌浓度。
