Fitoussi F, Doit C, Geslin P, Bingen E
Service de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
Antimicrob Agents Chemother. 1999 Oct;43(10):2372-5. doi: 10.1128/AAC.43.10.2372.
The killing activities of trovafloxacin alone and in combination with beta-lactam agents (extended-spectrum cephalosporins, meropenem), rifampin, or vancomycin were evaluated against 20 genotypically characterized Streptococcus pneumoniae isolates for which amoxicillin MICs were >/=4 microg/ml (cefotaxime MICs, >/=4 microg/ml for six strains) at concentrations clinically achievable in cerebrospinal fluid. At 6 h the mean killing activity of trovafloxacin alone (range, 2.6 to 2.9 log(10) CFU/ml) did not vary significantly according to the susceptibility of the strains to beta-lactam agents. The activities of trovafloxacin or vancomycin added to the beta-lactam agents and the combination trovafloxacin-vancomycin were additive or indifferent. Against the ceftriaxone-resistant isolates, the killing activity of the combination of a beta-lactam agent and trovafloxacin did not differ significantly from that of a beta-lactam agent and vancomycin.
单独使用曲伐沙星以及将其与β-内酰胺类药物(广谱头孢菌素、美罗培南)、利福平或万古霉素联合使用时,针对20株经基因分型鉴定的肺炎链球菌分离株进行了杀菌活性评估,这些分离株的阿莫西林最低抑菌浓度(MIC)≥4μg/ml(6株菌株的头孢噻肟MIC≥4μg/ml),评估时采用的是脑脊液中可达到的临床浓度。6小时时,单独使用曲伐沙星的平均杀菌活性(范围为2.6至2.9 log₁₀CFU/ml)根据菌株对β-内酰胺类药物的敏感性不同而无显著差异。添加到β-内酰胺类药物中的曲伐沙星或万古霉素以及曲伐沙星-万古霉素组合的活性呈相加或无差异。对于耐头孢曲松的分离株,β-内酰胺类药物与曲伐沙星组合的杀菌活性与β-内酰胺类药物与万古霉素组合的杀菌活性无显著差异。