Pinnock Hilary, Juniper Elizabeth F, Sheikh Aziz
Division of Community Health Sciences, GP Section, University of Edinburgh, 20, West Richmond Street, Edinburgh, EH8 9DX, UK.
J Clin Epidemiol. 2005 Aug;58(8):809-14. doi: 10.1016/j.jclinepi.2005.01.010.
There is increasing international interest in using patient-based outcome measures to evaluate interventions. We compared responses to postal administration of Mini Asthma Quality of Life Questionnaire (MiniAQLQ) and Asthma Control Questionnaire (ACQ) with the gold standard of supervised self-completion.
Validation study involving 96 adults, recruited from U.K. general practice, sent the postal questionnaires with an instruction sheet 1 week before supervised self-completion. Responses for those whose quality of life (n=56) or asthma control (n=61) had 'not changed' between postal and supervised completions were compared using paired-sample t-tests, Pearson's correlation coefficient (r), and intraclass correlation coefficient (ICC).
For the MiniAQLQ, overall mean scores were similar in both groups: Postal=5.14 (SD=1.42) vs. Supervised=5.17 (SD=1.39), with mean difference of -0.03 (95% CI=-0.14, 0.08; P=.59), with a high degree of correlation (r=.96, P<.001) and concordance (ICC=0.96; 95% CI=0.93, 0.98; P<.001). For the ACQ, overall mean scores (with SD) were also similar in both groups: Postal=1.24 (SD=1.09) vs. Supervised=1.26 (SD=1.10), with mean difference of -0.02 (95% CI=-0.12, 0.08; P=.74), with good correlation (r=.94, P<.01) and concordance (ICC=0.94; 95% CI=0.90, 0.96; P<.01).
Correlation and concordance between supervised and postal administration of the MiniAQLQ and ACQ are very high. Users may confidently choose the mode of administration most appropriate to their needs.
国际上越来越关注使用基于患者的结局指标来评估干预措施。我们将通过邮寄方式发放的简易哮喘生活质量问卷（MiniAQLQ）和哮喘控制问卷（ACQ）的应答情况与监督下自行填写这一黄金标准进行了比较。
一项验证性研究，涉及从英国全科医疗诊所招募的96名成年人，在监督下自行填写问卷前1周向他们发送附有指导说明的邮寄问卷。使用配对样本t检验、Pearson相关系数（r）和组内相关系数（ICC）对在邮寄填写和监督填写之间生活质量（n = 56）或哮喘控制情况（n = 61）“无变化”者的应答进行比较。
对于MiniAQLQ，两组的总体平均得分相似：邮寄填写组为5.14（标准差 = 1.42），监督填写组为5.17（标准差 = 1.39），平均差异为 -0.03（95%置信区间 = -0.14, 0.08；P = 0.59），具有高度相关性（r = 0.96，P < 0.001）和一致性（ICC = 0.96；95%置信区间 = 0.93, 0.98；P < 0.001）。对于ACQ，两组的总体平均得分（及标准差）也相似：邮寄填写组为1.24（标准差 = 1.09），监督填写组为1.26（标准差 = 1.10），平均差异为 -0.02（95%置信区间 = -0.12, 0.08；P = 0.74），具有良好相关性（r = 0.94，P < 0.01）和一致性（ICC = 0.94；95%置信区间 = 0.90, 0.96；P < 0.01）。
MiniAQLQ和ACQ在监督填写和邮寄填写之间的相关性和一致性非常高。使用者可以放心地选择最适合其需求的填写方式。
