Verschaeve L
Vito, Environmental Toxicology, Mol, Belgium.
Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):336-41. doi: 10.1016/j.taap.2005.03.028.
The possible effects of radiofrequency (RF) exposure on the genetic material of cells are considered very important since damage to the DNA of somatic cells can be linked to cancer development or cell death whereas damage to germ cells can lead to genetic damage in next and subsequent generations. This is why the scientific literature reports many investigations on the subject. According to a number of review papers, the conclusion so far is that there is little evidence that RFR is directly mutagenic and that adverse effects that were reported in some of the papers are predominantly the result of hyperthermia. Yet, some subtle indirect effects on DNA replication and/or transcription of genes under relatively restricted exposure conditions cannot be ruled out. Furthermore, the possibility of combined effects of RFR with environmental carcinogens/mutagens merits further attention. The present paper takes into account more recent investigations but the conclusion remains the same. A majority of studies report no increased (cyto)genetic damage but yet, a considerable number of investigations do. However, many studies were not sufficiently characterized, are therefore difficult to replicate and cannot be compared to others. Experimental protocols were very different from one study to another and investigations from a single laboratory were very often limited in the sample size or number of cells investigated, preventing a robust statistical analysis. Subtle, but significant differences between RFR-exposed and sham-exposed cells cannot be found in such conditions. For the above reasons, it was concluded at a workshop in Löwenstein (November 2002) that further investigations by individual laboratories most probably will not add much to the discussion of radiofrequency radiation (RFR) genotoxicity. Large, well coordinated, international collaborative studies involving participation of several experienced scientists are considered an alternative of uttermost importance. One such study is now being planned.
射频（RF）辐射对细胞遗传物质可能产生的影响被认为非常重要，因为体细胞DNA的损伤可能与癌症发展或细胞死亡有关，而生殖细胞的损伤可能导致下一代及后续世代的遗传损伤。这就是为什么科学文献报道了许多关于该主题的研究。根据一些综述论文，目前的结论是，几乎没有证据表明射频辐射具有直接致突变性，而且一些论文中报道的不良反应主要是热疗的结果。然而，在相对受限的暴露条件下，对DNA复制和/或基因转录的一些细微间接影响也不能排除。此外，射频辐射与环境致癌物/诱变剂的联合作用可能性值得进一步关注。本文考虑了更多近期的研究，但结论仍然相同。大多数研究报告（细胞）遗传损伤没有增加，但仍有相当数量的调查显示有增加。然而，许多研究的特征描述不够充分，因此难以重复，也无法与其他研究进行比较。不同研究的实验方案差异很大，而且单个实验室的研究通常在样本量或所研究细胞数量方面有限，这妨碍了进行有力的统计分析。在这种情况下，无法发现暴露于射频辐射的细胞与假暴露细胞之间细微但显著的差异。基于上述原因，在洛温施泰因举行的一次研讨会上（2002年11月）得出结论，单个实验室的进一步研究很可能不会对射频辐射（RFR）遗传毒性的讨论增加太多内容。涉及多位经验丰富科学家参与的大规模、协调良好的国际合作研究被认为是极其重要的替代方案。目前正在计划开展一项这样的研究。
