Kyriazi Maria, Yova Dido, Rallis Michail, Lima A
School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 157 80 Athens, Greece.
Cancer Lett. 2006 Jun 18;237(2):234-41. doi: 10.1016/j.canlet.2005.06.005. Epub 2005 Jul 12.
The bark extract of Pinus Maritima (PBE), a rich in phenolic acids, polyphenols and in particular flavonoids mixture, was examined for skin cancer preventive action that was evaluated in two different experimental animal tumor models induced by ultraviolet radiation (UVR) and combination of UVR with 7,12-dimethylbenz[a]anthracene. Significant decrease in the number of animals bearing tumors and the number of tumors per animal was observed in the PBE treated animals. In the same time significant increase in the viability of these animals was also observed. Furthermore, PBE delayed the appearance of tumors. These results provide strong evidence about the preventive anticancer activity of this extract on non-melanoma skin cancer and its protective effect not only from UVR, but also from more potent carcinogenic agents.
滨海松树皮提取物（PBE）富含酚酸、多酚，尤其是黄酮类混合物，研究了其对皮肤癌的预防作用，并在两种不同的实验动物肿瘤模型中进行评估，这两种模型分别由紫外线辐射（UVR）以及UVR与7,12-二甲基苯并[a]蒽联合诱导。在接受PBE处理的动物中，观察到荷瘤动物数量和每只动物的肿瘤数量显著减少。同时，还观察到这些动物的存活率显著提高。此外，PBE延迟了肿瘤的出现。这些结果为该提取物对非黑素瘤皮肤癌的预防性抗癌活性及其不仅对UVR，而且对更强致癌剂的保护作用提供了有力证据。
