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富含碧萝芷™和提取物的凝胶敷料伤口愈合功效的体内评估

In Vivo Evaluation of Wound Healing Efficacy of Gel-Based Dressings Loaded with Pycnogenol™ and Extracts.

作者信息

Vitsos Andreas, Ieronymaki Dimitra, Kostaki Maria, Almpani Chara, Barda Christina, Kikionis Stefanos, Sfiniadakis Ioannis, Dallas Paraskevas, Rallis Michail Christou

机构信息

Section of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece.

Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece.

出版信息

Gels. 2024 Mar 28;10(4):233. doi: 10.3390/gels10040233.

DOI:10.3390/gels10040233
PMID:38667652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11048808/
Abstract

and French maritime pine bark (Pycnogenol™) extracts are considered promising therapeutic agents in wound healing. This study explores the healing efficacy of composite dressings containing these extracts, aiming to enhance their stability and effectiveness, utilizing a low-temperature vacuum method for producing Sodium Alginate-Maltodextrin gel dressings. Surgical wounds were inflicted on SKH-hr2 hairless mice. Dressings were loaded with Pycnogenol™ and/or extracts and assessed for their efficacy. Wound healing was primarily evaluated by clinical and histopathological evaluation and secondarily by Antera 3D camera and biophysical measurements. Dressings were stable and did not compromise the therapeutic properties of extract. All interventions were compared to the ointment as a reference product. Most of the wounds treated with the reference formulation and the dressing had already closed by the 15th day, with histological scores of 7 and 6.5, respectively. In contrast, wounds treated with Pycnogenol™, either alone or in combination with did not close by the end of the experiment (16th day), with histological scores reaching 15 in both cases. Furthermore, treatment with 5% Pycnogenol™ dressing appeared to induce skin thickening and increase body temperature. The study underscores the wound healing potential of extracts and highlights the need for further research to optimize Pycnogenol™ dosing in topical applications.

摘要

法国滨海松树皮提取物（碧萝芷™）被认为是伤口愈合方面有前景的治疗剂。本研究探索含有这些提取物的复合敷料的愈合效果，旨在提高其稳定性和有效性，采用低温真空法制备海藻酸钠 - 麦芽糊精凝胶敷料。对SKH - hr2无毛小鼠造成手术伤口。敷料中加入碧萝芷™和/或提取物并评估其疗效。伤口愈合主要通过临床和组织病理学评估，其次通过Antera 3D相机和生物物理测量进行评估。敷料稳定且不影响提取物的治疗特性。所有干预措施均与作为参考产品的软膏进行比较。用参考制剂和敷料治疗的大多数伤口在第15天已经愈合，组织学评分分别为7和6.5。相比之下，单独或与提取物联合使用碧萝芷™治疗的伤口在实验结束时（第16天）未愈合，两种情况下组织学评分均达到15。此外，用5%碧萝芷™敷料治疗似乎会导致皮肤增厚并升高体温。该研究强调了提取物的伤口愈合潜力，并突出了进一步研究以优化碧萝芷™局部应用剂量的必要性。

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