Küpeli Esra, Harput U Sebnem, Varel Mehtap, Yesilada Erdem, Saracoglu Iclal
Gazi University, Faculty of Pharmacy, Etiler 06330 Ankara, Turkey.
J Ethnopharmacol. 2005 Nov 14;102(2):170-6. doi: 10.1016/j.jep.2005.05.042. Epub 2005 Jul 12.
Extracts obtained from the herbs of various Veronica species are used as folk remedy worldwide for the treatment of various inflammatory ailments including rheumatism. In vivo anti-inflammatory and antinociceptive activities of Veronica anagallis-aquatica L. aerial parts were investigated. Methanolic extract of the plant was shown to possess significant inhibitory activity against carrageenan-induced hind paw edema model and of p-benzoquinone-induced writhings in mice. Through bioassay-guided fractionation and isolation procedures eight compounds, aquaticoside A (1), aquaticoside B (2), aquaticoside C (3), veronicoside (4), catalposide (5), verproside (6), verminoside (7) and martynoside (8) were isolated and their structures were elucidated by spectral techniques. Catapol derivative iridoid glucosides, verproside (6) and catalposide (5), were found to possess potent antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity as well as gastric damage. Results of the present study supported the utilization of the plant in Turkish folk medicine.
从各种婆婆纳属植物的草药中提取的提取物在全球范围内被用作民间药物，用于治疗包括风湿病在内的各种炎症性疾病。对水苦荬地上部分的体内抗炎和抗伤害感受活性进行了研究。该植物的甲醇提取物对卡拉胶诱导的小鼠后爪水肿模型和对苯醌诱导的小鼠扭体反应具有显著的抑制活性。通过生物测定指导的分级分离和分离程序，分离出了8种化合物，即水苦荬苷A（1）、水苦荬苷B（2）、水苦荬苷C（3）、婆婆纳苷（4）、梓醇（5）、毛蕊花糖苷（6）、豆叶苷（7）和紫葳苷（8），并通过光谱技术阐明了它们的结构。发现梓醇衍生物环烯醚萜苷、毛蕊花糖苷（6）和梓醇（5）具有强大的抗伤害感受和抗炎活性，口服时不会引起任何明显的急性毒性以及胃损伤。本研究结果支持了该植物在土耳其民间医学中的应用。
