Papiol Sergi, Molina Vicente, Desco Manuel, Rosa Araceli, Reig Santiago, Gispert Juan D, Sanz Javier, Palomo Tomás, Fañanás Lourdes
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.
Neuroimage. 2005 Oct 1;27(4):1002-6. doi: 10.1016/j.neuroimage.2005.05.035.
Magnetic resonance imaging (MRI) studies have shown some morphological and volumetric peculiarities in brains of schizophrenic patients. The authors explored the influence of genetic polymorphisms at interleukin-1beta (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) genes on these abnormalities. Hippocampus, lateral ventricles, and dorsolateral prefrontal cortex gray matter volumes were measured in a sample of 23 DSM-IV diagnosed schizophrenic patients of Spanish origin using MRI scans; MRI data were adjusted for age and brain volume using regression parameters from a healthy control group (n = 45). IL-1B and IL-1RN genes, involved in neurodevelopment and neurodegenerative processes, were analyzed in the patient sample. Patients carrying VNTR-allele*2 of IL-1RN gene showed a significant enlargement of both left (P = 0.002) and right (P = 0.01) ventricles. Sex and illness duration were controlled for in the analyses. Our results, though preliminary, suggest that IL-1RN gene might contribute to the ventricular volumetric changes observed in schizophrenic patients.
磁共振成像（MRI）研究显示，精神分裂症患者的大脑存在一些形态学和体积上的异常。作者探究了白细胞介素-1β（IL-1B）和白细胞介素-1受体拮抗剂（IL-1RN）基因的遗传多态性对这些异常情况的影响。使用MRI扫描对23名诊断为DSM-IV的西班牙裔精神分裂症患者进行了海马体、侧脑室和背外侧前额叶皮质灰质体积的测量；利用来自健康对照组（n = 45）的回归参数对MRI数据进行年龄和脑容量的校正。对患者样本中参与神经发育和神经退行性过程的IL-1B和IL-1RN基因进行了分析。携带IL-1RN基因VNTR-等位基因*2的患者，其左心室（P = 0.002）和右心室（P = 0.01）均显著增大。分析中对性别和病程进行了控制。我们的结果虽然是初步的，但表明IL-1RN基因可能与精神分裂症患者观察到的脑室体积变化有关。
