白细胞介素-1受体拮抗剂（IL-1RN）和白细胞介素-1β（IL-1B）基因多态性与创伤性脑损伤后的脑出血事件

IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury.

作者信息

Hadjigeorgiou G M, Paterakis K, Dardiotis E, Dardioti M, Aggelakis K, Tasiou A, Xiromerisiou G, Komnos A, Zintzaras E, Scarmeas N, Papadimitriou A, Karantanas A

机构信息

Department of Neurology, University Hospital of Larissa, Medical School, University of Thessaly, Larissa 41222, Greece.

出版信息

Neurology. 2005 Oct 11;65(7):1077-82. doi: 10.1212/01.wnl.0000178890.93795.0e.

DOI:10.1212/01.wnl.0000178890.93795.0e

PMID:16217062

Abstract

OBJECTIVE

To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI).

METHODS

Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant.

RESULTS

Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI (adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant.

CONCLUSION

There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.

摘要

目的

探讨白细胞介素（IL）1RN基因可变数目串联重复序列（VNTR）及IL-1B基因（-511）多态性与创伤性脑损伤（TBI）后脑出血事件的相关性。

方法

收集151例前瞻性招募的TBI患者的脑CT数据、入院时格拉斯哥昏迷量表（GCS）评分、6个月时格拉斯哥预后量表（GOS）评分及改良Rankin量表（mRS）评分。采用标准方法测定IL-1RN和IL-1B基因型。主要观察指标为是否发生任何类型的脑出血。脑出血类型、入院时GCS评分、6个月时GOS评分及mRS评分作为次要观察指标。采用逻辑回归分析计算比值比（OR）及相应的95%置信区间（CI）。在调整模型中，对年龄、性别、弥漫性脑水肿、颅内血肿体积、神经外科干预及入院时GCS评分进行校正。p值小于0.01被认为具有统计学意义。