一名急性早幼粒细胞白血病患儿接受全反式维甲酸治疗后出现生殖器溃疡。

Genital ulcers after treatment with all-trans-retinoic acid in a child with acute promyelocytic leukemia.

作者信息

Unal Selma, Gümrük Fatma, Cetin Mualla, Hiçsönmez Gönül

机构信息

Hacettepe University Faculty of Medicine, Department of Pediatrics, Section of Pediatric Hematology, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.

出版信息

Pediatr Hematol Oncol. 2005 Jul-Aug;22(5):357-9. doi: 10.1080/08880010590964138.

DOI:10.1080/08880010590964138

PMID:16020125

Abstract

All-trans-retinoic acid (ATRA) has been shown to improve the outcome of patients with acute promyelocytic leukemia (APL). However, various adverse effects of ATRA treatment have been noted, such as scrotal and genital ulcers in adult patients. The authors report genital ulcers that developed in a child with APL after ATRA treatment. An 8-year-old girl with APL was treated with ATRA for 21 days and after discontinuation of ATRA treatment she developed genital ulcers. Systemic and local antibiotic pomades were applied and the lesions improved within 15 days. In conclusion, genital ulcers may develop in children with APL as a complication of ATRA treatment and physicians should be alert to this possibility.

摘要

全反式维甲酸（ATRA）已被证明可改善急性早幼粒细胞白血病（APL）患者的治疗结果。然而，已注意到ATRA治疗存在各种不良反应，如成年患者出现阴囊和生殖器溃疡。作者报告了一名APL患儿在接受ATRA治疗后出现的生殖器溃疡。一名8岁的APL女童接受了21天的ATRA治疗，在停止ATRA治疗后出现了生殖器溃疡。应用了全身性和局部抗生素软膏，病变在15天内有所改善。总之，APL患儿可能会出现生殖器溃疡作为ATRA治疗的并发症，医生应警惕这种可能性。