Camargo Rodrigo Pauperio Soares de, Simões José Antonio, Cecatti José Guilherme, Alves Valéria Moraes Nader, Faro Sebastian
Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
Sao Paulo Med J. 2005 May 2;123(3):108-12. doi: 10.1590/s1516-31802005000300004. Epub 2005 Jul 8.
Bacterial vaginosis has been associated with prematurity and other perinatal complications. However, the efficacy of the treatment for preventing such complications has not yet been well established. The objective of this study was to evaluate the impact of treatment for bacterial vaginosis on a low-risk population of Brazilian pregnant women, in order to prevent prematurity and other perinatal complications.
Observational retrospective cohort study, at the Obstetric and Gynecology Department, Universidade Estadual de Campinas (Unicamp).
Vaginal bacterioscopy results from 785 low-risk pregnant women were studied. Three different groups of women were identified: 580 without bacterial vaginosis during pregnancy, 134 with bacterial vaginosis treated using imidazoles (metronidazole, tinidazole, or secnidazole) during pregnancy, and 71 with bacterial vaginosis not treated during pregnancy. The diagnosis of bacterial vaginosis was based on Nugent's criteria, from the vaginal bacterioscopy performed during the first prenatal care visit.
The frequency of prematurity was 5.5% among the women without bacterial vaginosis, 22.5% among those with untreated bacterial vaginosis and 3.7% among those with treated bacterial vaginosis. The risk ratios for perinatal complications were significantly higher in the group with untreated bacterial vaginosis: premature rupture of membranes, 7.5 (95% CI: 1.9-34.9); preterm labor, 3.4 (95% CI: 1.4-8.1); preterm birth, 6.0 (95% CI: 1.9-19.7); and low birth weight, 4.2 (95% CI: 1.2-14.3).
The treatment of bacterial vaginosis significantly reduced the rates of prematurity and other perinatal complications among these low-risk Brazilian pregnant women, regardless of the history of previous preterm delivery.
细菌性阴道病与早产及其他围产期并发症有关。然而，治疗对于预防此类并发症的疗效尚未得到充分证实。本研究的目的是评估细菌性阴道病治疗对巴西低风险孕妇群体的影响，以预防早产及其他围产期并发症。
在坎皮纳斯州立大学（Unicamp）妇产科进行的观察性回顾性队列研究。
研究了785名低风险孕妇的阴道细菌学检查结果。确定了三组不同的女性：580名孕期无细菌性阴道病的女性，134名孕期使用咪唑类药物（甲硝唑、替硝唑或塞克硝唑）治疗细菌性阴道病的女性，以及71名孕期未治疗细菌性阴道病的女性。细菌性阴道病的诊断基于首次产前检查时进行的阴道细菌学检查的 Nugent 标准。
无细菌性阴道病的女性早产发生率为5.5%，未治疗细菌性阴道病的女性为%，治疗细菌性阴道病的女性为3.7%。未治疗细菌性阴道病的组围产期并发症的风险比显著更高：胎膜早破，7.5（95%置信区间：1.9 - 34.9）；早产，3.4（95%置信区间：1.4 - 8.1）；早产，6.0（95%置信区间：1.9 - 19.7）；低出生体重，4.2（95%置信区间：1.2 - 14.3）。
细菌性阴道病的治疗显著降低了这些巴西低风险孕妇的早产率及其他围产期并发症的发生率，无论既往早产史如何。
