Ajaj Waleed, Lauenstein Thomas C, Schneemann Hubert, Kuehle Christiane, Herborn Christoph U, Goehde Susanne C, Ruehm Stefan G, Goyen Mathias
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital of Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Eur Radiol. 2005 Oct;15(10):2079-87. doi: 10.1007/s00330-005-2838-2. Epub 2005 Jul 14.
The aim of our study was to assess the effect of oral and rectal stool softeners on dark-lumen magnetic resonance (MR) colonography without bowel cleansing. Ten volunteers underwent MR colonography without colonic cleansing. A baseline examination was performed without oral or rectal administration of stool softeners. In a second set, volunteers ingested 60 ml of lactulose 24 h prior to MR examination. In a third examination, water as a rectal enema was replaced by a solution of 0.5%-docusate sodium (DS). A fourth MR examination was performed, in conjunction with both oral administration of lactulose and rectal application of DS. A T1-weighted data set was acquired at scanning times of 0, 5 and 10 min after colonic filling. A fourth data set was acquired 75 s after i.v. injection of contrast agent. Signal intensity of stool was calculated for all colonic segments. Without oral ingestion of lactulose or rectal enema with DS stool signal intensity was high and did not decrease over time. However, lactulose and DS caused a decrease in stool signal intensity. Both substances together led to a decreasing signal intensity of feces. Combination of lactulose and DS provided the lowest signal intensity of stool. Thus, feces could hardly be distinguished from dark rectal enema allowing for the assessment of the colonic wall.
我们研究的目的是评估口服和直肠使用大便软化剂对未进行肠道清洁的暗腔磁共振（MR）结肠成像的影响。十名志愿者接受了未进行结肠清洁的MR结肠成像检查。在未口服或直肠给予大便软化剂的情况下进行了基线检查。在第二组检查中，志愿者在MR检查前24小时摄入60毫升乳果糖。在第三次检查中，用0.5%的多库酯钠（DS）溶液替代直肠灌肠用水。进行了第四次MR检查，同时口服乳果糖并直肠应用DS。在结肠充盈后0、5和10分钟的扫描时间采集了T1加权数据集。在静脉注射造影剂75秒后采集了第四个数据集。计算了所有结肠段的粪便信号强度。在未口服乳果糖或未用DS进行直肠灌肠时，粪便信号强度较高且未随时间降低。然而，乳果糖和DS导致粪便信号强度降低。两种物质共同作用使粪便信号强度降低。乳果糖和DS的组合使粪便信号强度最低。因此，粪便几乎无法与暗的直肠灌肠剂区分开来，从而能够评估结肠壁。
