Saebø A, Lassen J
Institute of Surgery, Bergen University Hospital, Norway.
J Intern Med. 1992 May;231(5):531-5. doi: 10.1111/j.1365-2796.1992.tb00969.x.
During the period 1974-1983, Yersinia enterocolitica infection was diagnosed in 458 hospitalized patients by antibody response or isolation of the micro-organism. A total of 54 (11.9%) patients had acute liver infection, with significantly elevated serum levels (greater than or equal to 2-fold) of bilirubin and/or enzyme levels. Serious liver disease with cellular necrosis was observed in biopsy specimens from two of 12 patients examined; six had unspecific changes. The patients were followed up for 4-14 years (until 1987). A total of 22 (4.9%) patients were readmitted with chronic liver disease; in one case non-specific microscopic changes developed into granulomatous hepatitis over a period of 3 years. In both the acute and chronic stages of disease, liver involvement was associated with involvement of other organ systems, and some patients developed multi-organ disease. Chronic liver disease was associated with positive tests for antinuclear antibody and rheumatoid factor, and with a high mortality.
在1974年至1983年期间，通过抗体反应或微生物分离，在458名住院患者中诊断出小肠结肠炎耶尔森菌感染。共有54名（11.9%）患者出现急性肝脏感染，血清胆红素水平和/或酶水平显著升高（大于或等于2倍）。在接受检查的12名患者中的2名患者的活检标本中观察到伴有细胞坏死的严重肝脏疾病；6名患者有非特异性变化。对这些患者进行了4至14年的随访（直至1987年）。共有22名（4.9%）患者因慢性肝病再次入院；在1例病例中，非特异性显微镜下变化在3年时间里发展为肉芽肿性肝炎。在疾病的急性期和慢性期，肝脏受累均与其他器官系统受累相关，一些患者发展为多器官疾病。慢性肝病与抗核抗体和类风湿因子检测呈阳性以及高死亡率相关。
