重度闭合性颅脑损伤幸存者执行功能和记忆障碍的脑相关性：一项单光子发射计算机断层扫描研究
Cerebral correlates of disturbed executive function and memory in survivors of severe closed head injury: a SPECT study.
作者信息
Goldenberg G, Oder W, Spatt J, Podreka I
机构信息
Universitätsklinik für Neurologie, Vienna, Austria.
出版信息
J Neurol Neurosurg Psychiatry. 1992 May;55(5):362-8. doi: 10.1136/jnnp.55.5.362.
Abstract
Thirty six patients in the chronic stage after severe closed head injury were examined with tests of executive function, memory, intelligence, and functional capacities in daily living. Correlations were sought between test results and Tc-99m-HMPAO uptake of frontal, temporal, and thalamic regions assessed by SPECT. Neither the number of significant correlation coefficients between memory tests and regional uptake nor that between temporal uptake and tests exceeded chance. For the remaining tests, correlations to thalamic regions were stronger than those to the frontal regions, and those to right brain regions stronger than those to homologous left brain regions. Relationships of thalamic isotope uptake to neuropsychological performance may reflect the impact of diffuse brain damage and particularly of diffuse axonal injury on mental capacities.
摘要
对36例重度闭合性颅脑损伤慢性期患者进行了执行功能、记忆、智力及日常生活功能能力测试。通过单光子发射计算机断层扫描（SPECT）评估额叶、颞叶和丘脑区域的锝-99m-六甲基丙二胺肟（Tc-99m-HMPAO）摄取情况，并寻找测试结果与该摄取情况之间的相关性。记忆测试与区域摄取之间、颞叶摄取与测试之间的显著相关系数数量均未超过随机概率。对于其余测试，与丘脑区域的相关性强于与额叶区域的相关性，与右脑区域的相关性强于与同源左脑区域的相关性。丘脑同位素摄取与神经心理表现之间的关系可能反映了弥漫性脑损伤尤其是弥漫性轴索损伤对心理能力的影响。
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