Robert P H, Migneco O, Benoit M, Darcourt J, Ellul E, Benoliel J, Bonhomme P, Aubin V, Bussiere F, Darcourt G
Department of Psychiatry, Nice University, Pavillon J, Hópital Pasteur, France.
Psychiatry Res. 1995 Nov 10;61(4):231-41. doi: 10.1016/0925-4927(95)02625-8.
Fifteen nondemented subjects with memory complaints underwent serial single photon emission computed tomography (SPECT) studies with technetium-99m-d, l-hexamethyl-propylene amine oxime (HMPAO) as tracer. Scans were carried out under a baseline conditions and during the learning phase of the Memory Efficiency Profile (MEP), a combined visual perception and memory task developed by Rey. Results indicate a positive correlation between activation, as indexed by HMPAO uptake, and neuropsychological assessment. Right temporal activation was correlated with MEP immediate recall. The right cerebellum was correlated with both MEP immediate and delayed recall. This study suggests that SPECT can show cortical activation during cognitive performance in subjects with mild memory impairment.
15名有记忆障碍主诉的非痴呆受试者接受了以锝-99m-d，l-六甲基丙烯胺肟（HMPAO）为示踪剂的系列单光子发射计算机断层扫描（SPECT）研究。扫描在基线条件下以及记忆效率剖面图（MEP）的学习阶段进行，MEP是由雷伊开发的一项结合视觉感知和记忆的任务。结果表明，以HMPAO摄取为指标的激活与神经心理学评估之间呈正相关。右侧颞叶激活与MEP即时回忆相关。右侧小脑与MEP即时和延迟回忆均相关。这项研究表明，SPECT可以显示轻度记忆障碍受试者在认知表现期间的皮质激活。
