Patel Keyur, Zekry Amany, McHutchison John G
Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, P.O. Box 17969, Durham, NC 27715, USA.
Clin Liver Dis. 2005 Aug;9(3):399-410, vi. doi: 10.1016/j.cld.2005.05.007.
Chronic hepatitis C (CHC) and steatosis are common entities that have the potential to interact synergistically and result in significant morbidity. Steatosis is frequently observed in CHC and seems to have a significant impact on the natural history of the disease with respect to development of fibrosis and reducing the virologic response to current therapy. Research efforts should continue to focus on delineating the complex viral and host interactions involved in the pathogenesis of hepatitis C virus (HCV)-related steatosis. This may provide novel future therapeutic strategies that may help modulate disease progression in relation to steatosis in HCV infection.
慢性丙型肝炎（CHC）和脂肪变性是常见病症，它们有可能产生协同作用并导致严重的发病情况。脂肪变性在CHC中经常被观察到，并且似乎对疾病的自然史在纤维化发展以及降低对当前治疗的病毒学反应方面有重大影响。研究工作应继续专注于阐明丙型肝炎病毒（HCV）相关脂肪变性发病机制中涉及的复杂病毒与宿主相互作用。这可能会提供新的未来治疗策略，有助于调节HCV感染中与脂肪变性相关的疾病进展。
