Kokturk Oguz, Ciftci Tansu Ulukavak, Mollarecep Elif, Ciftci Bulent
Faculty of Medicine, Department of Pulmonary Disease, Gazi University, Besevler, Ankara, Turkey.
Respir Med. 2006 Mar;100(3):536-41. doi: 10.1016/j.rmed.2005.05.025. Epub 2005 Jul 15.
Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity and mortality. Elevated levels of serum homocysteine are also associated with cardiovascular morbidity and mortality. We aimed to investigate serum homocysteine levels and conventional cardiovascular risk factors (cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides) in OSAS patients with and without cardiovascular diseases (CVD).
Levels of homocysteine, cholesterol, LDL, HDL and triglycerides were measured in 114 obese, male participants after overnight fasting. The presence of OSAS was determined by standard overnight polysomnography. The cases included OSAS patients (apnea-hypopnea index: AHI5) with CVD (OSAS+CVD group) (n:25) and without CVD (OSAS-CVD group) (n:47). Control group was patients without OSAS (AHI<5) with CVD (CVD group) (n:42). The serum homocysteine levels were significant.
阻塞性睡眠呼吸暂停综合征（OSAS）与心血管疾病的发病率和死亡率相关。血清同型半胱氨酸水平升高也与心血管疾病的发病率和死亡率相关。我们旨在调查患有和未患有心血管疾病（CVD）的OSAS患者的血清同型半胱氨酸水平和传统心血管危险因素（胆固醇、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯）。
对114名肥胖男性参与者进行过夜禁食后，测量其同型半胱氨酸、胆固醇、LDL、HDL和甘油三酯水平。通过标准的过夜多导睡眠图确定是否存在OSAS。病例包括患有CVD的OSAS患者（呼吸暂停低通气指数：AHI≥5）（OSAS+CVD组）（n = 25）和未患有CVD的OSAS患者（OSAS-CVD组）（n = 47）。对照组为未患有OSAS（AHI<5）且患有CVD的患者（CVD组）（n = 42）。血清同型半胱氨酸水平具有显著差异。
