Yavuz Zekiye, Ursavaş Ahmet, Ege Ercüment, Ozarda Ilçol Yeşim, Karadağ Mehmet, Uzaslan Esra, Gözü R Oktay
Department of Chest Diseases, Faculty of Medicine, Uludağ University, Bursa, Turkey.
Tuberk Toraks. 2008;56(1):37-42.
The exact mechanism of development of cardiovascular disease in patients with obstructive sleep apnea syndrome (OSAS) remains to be unknown. The role of homocysteine in atherosclerotic disease process has become well established over the past ten years. Our aim was to study to compare homoscysteine levels between OSAS and control levels. Sixty-two subjects with OSAS and twelve similar controls in age, gender, body mass index, smoking and coronary heart disease were included in this prospective study. Serum levels of homocysteine (13.5 +/- 6.0 micromol/L vs. 10.2 +/- 2.9 micromol/L, p= 0.03) in the OSAS group were significantly greater than those in the control group. Logistic regression analyses showed that OSAS (Odds ratio: 9.08 95% CI 2.347-35.120; p= 0.001) was independent risk factors for high levels of serum homocysteine in age, smoking status, diabetes mellitus and coronary heart disease. We conclude that homocysteine may be an important factor for development of cardiovascular disease in patients with OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）患者心血管疾病的确切发病机制尚不清楚。在过去十年中，同型半胱氨酸在动脉粥样硬化疾病过程中的作用已得到充分证实。我们的目的是研究并比较OSAS患者与对照组的同型半胱氨酸水平。这项前瞻性研究纳入了62例OSAS患者以及12例在年龄、性别、体重指数、吸烟情况和冠心病方面与之相似的对照者。OSAS组的血清同型半胱氨酸水平（13.5±6.0微摩尔/升 vs. 10.2±2.9微摩尔/升，p = 0.03）显著高于对照组。逻辑回归分析显示，在年龄、吸烟状况、糖尿病和冠心病方面，OSAS（优势比：9.08，95%可信区间2.347 - 35.120；p = 0.001）是血清同型半胱氨酸水平升高的独立危险因素。我们得出结论，同型半胱氨酸可能是OSAS患者心血管疾病发生的一个重要因素。
