阻塞性睡眠呼吸暂停患者与对照组之间同型半胱氨酸水平的差异：一项荟萃分析。
The differences in homocysteine level between obstructive sleep apnea patients and controls: a meta-analysis.
作者信息
Niu Xun, Chen Xiong, Xiao Ying, Dong Jiaqi, Zhang Rui, Lu Meixia, Kong Weijia
机构信息
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
PLoS One. 2014 Apr 25;9(4):e95794. doi: 10.1371/journal.pone.0095794. eCollection 2014.
BACKGROUND
Studies have reported inconsistent findings regarding the relationship between obstructive sleep apnea (OSA) and homocysteine (HCY) level. This study aimed to assess the difference in plasma HCY level between OSA patients and controls by conducting a meta-analysis of published studies.
METHODS
Database of PubMed, SCI, and China National Knowledge Internet (CNKI) were comprehensively searched. Eligible studies regarding plasma HCY level in OSA patients were identified by two independent reviewers. RevMan (version 5.2) and STATA (version 12.0) were employed for data synthesis.
RESULTS
A total of 10 studies involving 432 subjects were included. Meta-analysis showed that plasma HCY levels in OSA group were 3.11 µmol/l higher than that in control group (95% confidence interval: 2.08 to 4.15, P<0.01). Subgroup analysis revealed a more significant differences between OSA patients and controls when average body mass index ≥ 30 (the total weighted mean difference (WMD) was 3.64), average age<50 (the total WMD was 3.96) and average apnea hypopnea index ≥ 35 (the total WMD was 4.54).
CONCLUSIONS
In this meta-analysis, plasma HCY levels were found to be higher in OSA patients compared to control subjects.
背景
关于阻塞性睡眠呼吸暂停（OSA）与同型半胱氨酸（HCY）水平之间的关系，研究报告的结果并不一致。本研究旨在通过对已发表研究进行荟萃分析，评估OSA患者与对照组之间血浆HCY水平的差异。
方法
全面检索了PubMed、SCI和中国知网（CNKI）数据库。由两名独立的评审员确定有关OSA患者血浆HCY水平的合格研究。采用RevMan（5.2版）和STATA（12.0版）进行数据合成。
结果
共纳入10项研究，涉及432名受试者。荟萃分析显示，OSA组的血浆HCY水平比对照组高3.11µmol/l（95%置信区间：2.08至4.15，P<0.01）。亚组分析显示，当平均体重指数≥30（总加权平均差（WMD）为3.64）、平均年龄<50（总WMD为3.96）和平均呼吸暂停低通气指数≥35（总WMD为4.54）时，OSA患者与对照组之间的差异更为显著。
结论
在这项荟萃分析中，发现OSA患者的血浆HCY水平高于对照组。
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