Jessen Frank, Traeber Frank, Freymann Nikolaus, Maier Wolfgang, Schild Hans-H, Heun Reinhard, Block Wolfgang
Department of Psychiatry, University of Bonn, Bonn, Germany.
Dement Geriatr Cogn Disord. 2005;20(2-3):178-83. doi: 10.1159/000087095. Epub 2005 Jul 15.
To investigate group differences and correlations and to determine the sensitivity and specificity of different measures of the neuronal marker N-acetylaspartate (NAA) in the medial temporal lobe of Alzheimer's Disease (AD) patients.
The metabolic ratio NAA/creatine (Cr), the absolute concentration of NAA referenced against brain tissue (BT) water and NAA multiplied with the amount of BT in the proton magnetic resonance spectroscopy (1H-MRS) voxel were assessed in patients and healthy controls with a single-voxel 1H-MRS protocol.
All measures were significantly lower in AD patients compared with controls. NAA/Cr and NAA correlated weakly, and there was no correlation of NAA with the amount of BT in the voxel. The highest specificity (87%) at a sensitivity of 80% was observed for NAA multiplied with the amount of BT in the voxel. There was no correlation of the MMSE with any of the NAA parameters.
NAA/Cr does not reflect NAA concentration very well. NAA is not correlated with brain atrophy. The BT volume in the 1H-MRS voxel in combination with the concentration of NAA discriminates AD from healthy controls sufficiently.
研究组间差异和相关性，并确定阿尔茨海默病（AD）患者内侧颞叶中神经元标志物N-乙酰天门冬氨酸（NAA）不同测量指标的敏感性和特异性。
采用单体素氢质子磁共振波谱（1H-MRS）方案，对患者和健康对照者评估代谢率NAA/肌酸（Cr）、以脑组织（BT）水为参照的NAA绝对浓度以及NAA与1H-MRS体素中BT量的乘积。
与对照组相比，AD患者的所有测量指标均显著降低。NAA/Cr与NAA呈弱相关，且NAA与体素中BT量无相关性。对于NAA与体素中BT量的乘积，在敏感性为80%时观察到最高特异性（87%）。简易精神状态检查表（MMSE）与任何NAA参数均无相关性。
NAA/Cr不能很好地反映NAA浓度。NAA与脑萎缩无关。1H-MRS体素中的BT体积与NAA浓度相结合足以区分AD患者与健康对照者。
