Horie S, Kamijou Y, Imai M, Hirai K, Honda T, Hayasaka S, Kobayashi T, Sekiguchi M
First Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Feb;30(2):347-51.
A 60-year-old man was admitted 1 hour after ingesting approximately 40 ml of Gramoxon (paraquat) in an attempt to commit suicide. Gastrointestinal lavage, compulsory urination, and direct hemoperfusion (DHP) were immediately performed to remove the paraquat. He was then administered Vitamin E and high dose methylprednisolone therapy to prevent lung injury. Chest roentgenogram on the 3rd day showed ground glass appearance in the outer zone of bilateral lung fields. Chest CT scans on the 9th day revealed a faint high density area in the same area, suggesting interstitial change. The shadows gradually improved and had disappeared on the 35th day after admission. Serum superoxide dismutase (SOD) activity, measured by electron spin resonance spectroscopy, was undetectably low until the 22nd day, and then increased into the normal range. It was suggested that SOD was consumed to neutralize the paraquat toxicity. Serum SOD activity changed according to the paraquat activity, and was a useful indicator of paraquat toxic activity. He was discharged without any symptoms 50 days after admission.
一名60岁男性在摄入约40毫升克芜踪（百草枯）企图自杀1小时后入院。立即进行了胃肠灌洗、强制排尿和直接血液灌流（DHP）以清除百草枯。随后给予他维生素E和大剂量甲基强的松龙治疗以预防肺损伤。第3天的胸部X线片显示双侧肺野外周出现磨玻璃样改变。第9天的胸部CT扫描显示同一区域有模糊的高密度区，提示间质改变。阴影逐渐改善，入院后第35天消失。通过电子自旋共振光谱法测定的血清超氧化物歧化酶（SOD）活性在第22天前一直低至检测不到，然后升至正常范围。提示SOD被消耗以中和百草枯毒性。血清SOD活性随百草枯活性而变化，是百草枯毒性活性的有用指标。入院50天后他无症状出院。
