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人体高度弯曲的动脉粥样硬化冠状动脉铸型中的血流测量。

Flow measurements in a highly curved atherosclerotic coronary artery cast of man.

作者信息

Back L H, Liem T K, Kwack E Y, Crawford D W

机构信息

Jet Propulsion Laboratory, California Institute of Technology, Pasadena 91109.

出版信息

J Biomech Eng. 1992 May;114(2):232-40. doi: 10.1115/1.2891377.

DOI:10.1115/1.2891377
PMID:1602767
Abstract

Flow visualization and wall pressure measurements were made in a polyurethane cast of a cadaver coronary artery with a significant "s" shaped reverse curvature. A sucrose solution was used to simulate the kinematic viscosity of blood, with flow rates in the physiologic range. Flow visualization demonstrated significant secondary flow patterns in the wall vicinity, which increased with increasing Reynolds number. Random dye dispersion was observed at a Reynolds number of about 400, but not at 200. Dye filament patterns in the transition between the first and second curved region were predominantly influenced by the second curved region at lower Reynolds numbers, and by the first curved region at higher Re. Local wall pressure measurements demonstrated a significant centrifugal effect with large radial pressure differences across the casting. Flow resistances for the casting were considerably greater than reference Poiseuille flow values, and increased further with pulsatile flow.

摘要

在一具具有明显“S”形反向曲率的尸体冠状动脉的聚氨酯铸型中进行了流动可视化和壁面压力测量。使用蔗糖溶液模拟血液的运动粘度,流速处于生理范围内。流动可视化显示在壁面附近存在显著的二次流模式,其随着雷诺数的增加而增强。在雷诺数约为400时观察到随机染料扩散,但在200时未观察到。在第一和第二弯曲区域之间的过渡处,染料细丝模式在较低雷诺数下主要受第二弯曲区域影响,而在较高雷诺数下受第一弯曲区域影响。局部壁面压力测量显示出显著的离心效应,铸型上存在较大的径向压力差。铸型的流动阻力远大于参考泊肃叶流值,并且随着脉动流进一步增加。

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