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[视网膜前视觉假体]

[Epiretinal visual prostheses].

作者信息

Walter P, Mokwa W

机构信息

Universitätsaugenklinik, RWTH, Aachen.

出版信息

Ophthalmologe. 2005 Oct;102(10):933-40. doi: 10.1007/s00347-005-1250-2.

DOI:10.1007/s00347-005-1250-2
PMID:16028058
Abstract

Epiretinal implants consist of a camera chip capturing the scene, a visual processor calculating retina-specific pulse sequences, a transponder for data and energy, and the implant itself. The implant consists of a receiver integrated into a posterior chamber lens, a microcable, and the retina stimulator. The stimulator is fixated onto the retinal surface using retinal tacks. In animal experiments it was shown that the materials being used were tolerated, the data and energy stream did not induce any adverse events, and that the fixation was feasible using retinal tacks. Stimulation of the inner retinal surface yielded a topographically correct activation of visual cortical areas. Even after a long history of blindness, tests in humans disclosed visual percepts.

摘要

视网膜外植入物由一个捕捉场景的摄像头芯片、一个计算视网膜特定脉冲序列的视觉处理器、一个用于数据和能量传输的应答器以及植入物本身组成。该植入物由一个集成在后房晶状体中的接收器、一根微电缆和视网膜刺激器组成。刺激器通过视网膜钉固定在视网膜表面。动物实验表明,所使用的材料具有耐受性,数据和能量流不会引发任何不良事件,并且使用视网膜钉进行固定是可行的。对视网膜内表面的刺激在视觉皮层区域产生了地形学上正确的激活。即使在长期失明之后,人体测试也揭示了视觉感知。

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Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):51-9. doi: 10.1007/s00417-011-1756-z. Epub 2011 Aug 23.
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Toward a wide-field retinal prosthesis.迈向广域视网膜假体。
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本文引用的文献

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A wavelet-based time-frequency analysis approach for classification of motor imagery for brain-computer interface applications.
J Neural Eng. 2005 Dec;2(4):65-72. doi: 10.1088/1741-2560/2/4/001. Epub 2005 Aug 15.
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Cortical activation via an implanted wireless retinal prosthesis.通过植入式无线视网膜假体实现的皮质激活。
Invest Ophthalmol Vis Sci. 2005 May;46(5):1780-5. doi: 10.1167/iovs.04-0924.
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Retino-cortical information transmission achievable with a retina implant.视网膜植入物可实现的视网膜-皮质信息传递。
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Retinal replacement--the development of microelectronic retinal prostheses--experience with subretinal implants and new aspects.视网膜置换——微电子视网膜假体的发展——视网膜下植入物的经验及新进展。
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Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials.短期手术试验期间使用微电极阵列对人视网膜进行电刺激的感知功效。
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Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays.使用微电极阵列对人视网膜进行短期电刺激的方法和感知阈值
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Pattern recognition with the optic nerve visual prosthesis.视神经视觉假体的模式识别
Artif Organs. 2003 Nov;27(11):996-1004. doi: 10.1046/j.1525-1594.2003.07305.x.
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Towards the cortical representation of form and motion stimuli generated by a retina implant.关于视网膜植入物产生的形状和运动刺激的皮质表征
Graefes Arch Clin Exp Ophthalmol. 2003 Aug;241(8):685-93. doi: 10.1007/s00417-003-0746-1. Epub 2003 Jul 29.
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Position, size and luminosity of phosphenes generated by direct optic nerve stimulation.由直接视神经刺激产生的光幻视的位置、大小和亮度。
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