Ameri Hossein, Ratanapakorn Tanapat, Ufer Stefan, Eckhardt Helmut, Humayun Mark S, Weiland James D
Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J Neural Eng. 2009 Jun;6(3):035002. doi: 10.1088/1741-2560/6/3/035002. Epub 2009 May 20.
The purpose of this paper is to present a wide field electrode array that may increase the field of vision in patients implanted with a retinal prosthesis. Mobility is often impaired in patients with low vision, particularly in those with peripheral visual loss. Studies on low vision patients as well as simulation studies on normally sighted individuals have indicated a strong correlation between the visual field and mobility. In addition, it has been shown that an increased visual field is associated with a significant improvement in visual acuity and object discrimination. Current electrode arrays implanted in animals or human vary in size; however, the retinal area covered by the electrodes has a maximum projected visual field of about 10 degrees. We have designed wide field electrode arrays that could potentially provide a visual field of 34 degrees, which may significantly improve the mobility. Tests performed on a mechanical eye model showed that it was possible to fix 10 mm wide flexible polyimide dummy electrode arrays onto the retina using a single retinal tack. They also showed that the arrays could conform to the inner curvature of the eye. Surgeries on an enucleated porcine eye model demonstrated feasibility of implantation of 10 mm wide arrays through a 5 mm eye wall incision.
本文的目的是介绍一种宽视野电极阵列,该阵列可能会扩大植入视网膜假体患者的视野。视力低下患者,尤其是周边视力丧失的患者,行动能力常常受到损害。针对视力低下患者的研究以及对视力正常个体的模拟研究表明,视野与行动能力之间存在很强的相关性。此外,研究表明,扩大视野与视力和物体辨别能力的显著改善相关。目前植入动物或人体的电极阵列大小各异;然而,电极覆盖的视网膜区域的最大投影视野约为10度。我们设计了宽视野电极阵列,有可能提供34度的视野,这可能会显著改善行动能力。在机械眼模型上进行的测试表明,使用单个视网膜钉可以将10毫米宽的柔性聚酰亚胺假电极阵列固定在视网膜上。测试还表明,这些阵列可以贴合眼球的内曲率。在摘除眼球的猪眼模型上进行的手术证明了通过5毫米的眼壁切口植入10毫米宽阵列的可行性。