Suppr超能文献

迈向广域视网膜假体。

Toward a wide-field retinal prosthesis.

作者信息

Ameri Hossein, Ratanapakorn Tanapat, Ufer Stefan, Eckhardt Helmut, Humayun Mark S, Weiland James D

机构信息

Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

出版信息

J Neural Eng. 2009 Jun;6(3):035002. doi: 10.1088/1741-2560/6/3/035002. Epub 2009 May 20.

Abstract

The purpose of this paper is to present a wide field electrode array that may increase the field of vision in patients implanted with a retinal prosthesis. Mobility is often impaired in patients with low vision, particularly in those with peripheral visual loss. Studies on low vision patients as well as simulation studies on normally sighted individuals have indicated a strong correlation between the visual field and mobility. In addition, it has been shown that an increased visual field is associated with a significant improvement in visual acuity and object discrimination. Current electrode arrays implanted in animals or human vary in size; however, the retinal area covered by the electrodes has a maximum projected visual field of about 10 degrees. We have designed wide field electrode arrays that could potentially provide a visual field of 34 degrees, which may significantly improve the mobility. Tests performed on a mechanical eye model showed that it was possible to fix 10 mm wide flexible polyimide dummy electrode arrays onto the retina using a single retinal tack. They also showed that the arrays could conform to the inner curvature of the eye. Surgeries on an enucleated porcine eye model demonstrated feasibility of implantation of 10 mm wide arrays through a 5 mm eye wall incision.

摘要

本文的目的是介绍一种宽视野电极阵列,该阵列可能会扩大植入视网膜假体患者的视野。视力低下患者,尤其是周边视力丧失的患者,行动能力常常受到损害。针对视力低下患者的研究以及对视力正常个体的模拟研究表明,视野与行动能力之间存在很强的相关性。此外,研究表明,扩大视野与视力和物体辨别能力的显著改善相关。目前植入动物或人体的电极阵列大小各异;然而,电极覆盖的视网膜区域的最大投影视野约为10度。我们设计了宽视野电极阵列,有可能提供34度的视野,这可能会显著改善行动能力。在机械眼模型上进行的测试表明,使用单个视网膜钉可以将10毫米宽的柔性聚酰亚胺假电极阵列固定在视网膜上。测试还表明,这些阵列可以贴合眼球的内曲率。在摘除眼球的猪眼模型上进行的手术证明了通过5毫米的眼壁切口植入10毫米宽阵列的可行性。

相似文献

1
Toward a wide-field retinal prosthesis.迈向广域视网膜假体。
J Neural Eng. 2009 Jun;6(3):035002. doi: 10.1088/1741-2560/6/3/035002. Epub 2009 May 20.
2
The eye and the chip 2008.《眼睛与芯片2008》
J Neural Eng. 2009 Jun;6(3):030201. doi: 10.1088/1741-2552/6/3/030201. Epub 2009 May 20.
3
Toward the development of a cortically based visual neuroprosthesis.迈向基于皮层的视觉神经假体的发展。
J Neural Eng. 2009 Jun;6(3):035001. doi: 10.1088/1741-2560/6/3/035001. Epub 2009 May 20.

引用本文的文献

5
Implantation of multiple suprachoroidal electrode arrays in rabbits.在兔子体内植入多个脉络膜上腔电极阵列。
J Curr Ophthalmol. 2017 Dec 9;30(1):68-73. doi: 10.1016/j.joco.2017.11.007. eCollection 2018 Mar.
7
Retinal prostheses: progress toward the next generation implants.视网膜假体:向新一代植入物迈进的进展。
Front Neurosci. 2015 Aug 20;9:290. doi: 10.3389/fnins.2015.00290. eCollection 2015.
8
Retinal prosthesis.视网膜假体
IEEE Trans Biomed Eng. 2014 May;61(5):1412-24. doi: 10.1109/TBME.2014.2314733. Epub 2014 Apr 2.
10
Task-dependent V1 responses in human retinitis pigmentosa.人类视网膜色素变性中与任务相关的V1反应。
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5356-64. doi: 10.1167/iovs.09-4775. Epub 2010 May 5.

本文引用的文献

1
Current trends in the management of intraocular foreign bodies.眼内异物处理的当前趋势
Curr Opin Ophthalmol. 2008 May;19(3):225-33. doi: 10.1097/ICU.0b013e3282fa75f1.
2
5
Real and virtual mobility performance in simulated prosthetic vision.模拟假肢视觉中的真实和虚拟移动性能。
J Neural Eng. 2007 Mar;4(1):S92-101. doi: 10.1088/1741-2560/4/1/S11. Epub 2007 Feb 26.
6
Optoelectronic retinal prosthesis: system design and performance.光电视网膜假体:系统设计与性能
J Neural Eng. 2007 Mar;4(1):S72-84. doi: 10.1088/1741-2560/4/1/S09. Epub 2007 Feb 26.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验