Hwang S-H, Oh H-B, Hur S-S, Lee M-N, Hong S-A, Kwon O-J
Department of Laboratory Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Tissue Antigens. 2005 Aug;66(2):145-7. doi: 10.1111/j.1399-0039.2005.00439.x.
In this report, we describe the identification of an HLA-A31 nucleotide sequence variant, a new HLA-A3111, in three members of a Korean family by using sequence-based typing (SBT). The new allele was detected during routine HLA typing by high-resolution SBT. Allele A3111 showed one nucleotide difference with A310102 at codon 165 (GTG-->CTG) resulting in an amino acid change from valine to leucine (V165L). Serologic reactivity was shorter than normally expected.
在本报告中，我们描述了通过基于序列的分型（SBT）在一个韩裔家庭的三名成员中鉴定出一种HLA - A31核苷酸序列变体，即一种新的HLA - A31:11。该新等位基因是在通过高分辨率SBT进行常规HLA分型过程中检测到的。等位基因A31:11在密码子165处与A31:01:02有一个核苷酸差异（GTG→CTG），导致氨基酸从缬氨酸变为亮氨酸（V165L）。血清学反应性比正常预期的要短。
