Camelo Serge, Kezic Jelena, McMenamin Paul G
School of Anatomy and Human Biology, The University of Western Australia, Perth, Western Australia, Australia.
Clin Exp Ophthalmol. 2005 Aug;33(4):426-32. doi: 10.1111/j.1442-9071.2005.01044.x.
Anterior chamber-associated immune deviation (ACAID) is an animal model of tolerance induced experimentally by the injection of antigen into the anterior chamber of the eye. The unusual deviant immune response has both afferent and efferent arms and it is the former that is the focus of this review. The paradigm states that antigen injected into the anterior chamber of the eye is internalized by intraocular antigen presenting cells (APCs) which then migrate largely to the spleen to induce the differentiation of regulatory T cell populations which in turn form the basis of the modified efferent arm to the deviant immune response. However, the migration routes of ocular APCs or free antigen to the secondary lymphoid organs remain unclear. In this review we will discuss the evidence for different possible afferent routes by which antigen (either free or cell-associated) leaves the eye and the pattern of distribution to secondary lymphoid organs.
前房相关免疫偏离（ACAID）是一种通过将抗原注射到眼前房而实验性诱导产生耐受的动物模型。这种异常的偏离免疫反应既有传入臂又有传出臂，而本文综述的重点是前者。该模式表明，注射到眼前房的抗原被眼内抗原呈递细胞（APC）内化，这些细胞随后大多迁移至脾脏，诱导调节性T细胞群体的分化，进而构成偏离免疫反应中改变的传出臂的基础。然而，眼内APC或游离抗原向次级淋巴器官的迁移途径仍不清楚。在本综述中，我们将讨论关于抗原（游离或与细胞相关）离开眼睛并向次级淋巴器官分布的不同可能传入途径的证据。
