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橡皮圈套扎术与外剥内扎术治疗痔疮的对比

Rubber band ligation versus excisional haemorrhoidectomy for haemorrhoids.

作者信息

Shanmugam V, Thaha M A, Rabindranath K S, Campbell K L, Steele R J C, Loudon M A

机构信息

General / Colorectal surgery, Aberdeen Royal Infirmary / Aberdeen University, Ward 50, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Grampian, UK, AB25 2ZN.

出版信息

Cochrane Database Syst Rev. 2005 Jul 20;2005(3):CD005034. doi: 10.1002/14651858.CD005034.pub2.

Abstract

BACKGROUND

Traditional treatment methods for haemorrhoids fall into two broad groups: less invasive techniques including rubber band ligation (RBL), which tend to produce minimal pain, and the more radical techniques like excisional haemorrhoidectomy (EH), which are inherently more painful. For decades, innovations in the field of haemorrhoidal treatment have centred on modifying the traditional methods to achieve a minimally invasive, less painful procedure and yet with a more sustainable result. The availability of newer techniques has reopened debate on the roles of traditional treatment options for haemorrhoids.

OBJECTIVES

To review the efficacy and safety of the two most popular conventional methods of haemorrhoidal treatment, rubber band ligation and excisional haemorrhoidectomy.

SEARCH STRATEGY

We searched all the major electronic databases (MEDLINE, EMBASE, CENTRAL, CINAHL).

SELECTION CRITERIA

Randomised controlled trials comparing rubber band ligation with excisional haemorrhoidectomy for symptomatic haemorrhoids in adult human patients were included.

DATA COLLECTION AND ANALYSIS

We extracted data on to previously designed data extraction sheet. Dichtomous data were presented as relative risk and 95% confidence intervals, and continuous outcomes as weighted mean difference and 95% confidence intervals.

MAIN RESULTS

Three trials (of poor methodological quality) met the inclusion criteria. Complete remission of haemorrhoidal symptom was better with EH (three studies, 202 patients, RR 1.68, 95% CI 1.00 to 2.83). There was significant heterogeneity between the studies (I2 = 90.5%; P = 0.0001). Similar analysis based on the grading of haemorrhoids revealed the superiority of EH over RBL for grade III haemorrhoids (prolapse that needs manual reduction) (two trials, 116 patients, RR 1.23, CI 1.04 to 1.45; P = 0.01). However, no significant difference was noticed in grade II haemorrhoids (prolapse that reduces spontaneously on cessation of straining) (one trial, 32 patients, RR 1.07, CI 0.94 to 1.21; P = 0.32) Fewer patients required re-treatment after EH (three trials, RR 0.20 CI 0.09 to 0.40; P < 0.00001). Patients undergoing EH were at significantly higher risk of postoperative pain (three trials, fixed effect; 212 patients, RR 1.94, 95% CI 1.62 to 2.33, P < 0.00001). The overall delayed complication rate showed significant difference (P = 0.03) (three trials, 204 patients, RR 6.32, CI 1.15 to 34.89) between the two interventions.

AUTHORS' CONCLUSIONS: The present systematic review confirms the long-term efficacy of EH, at least for grade III haemorrhoids, compared to the less invasive technique of RBL but at the expense of increased pain, higher complications and more time off work. However, despite these disadvantages of EH, patient satisfaction and patient's acceptance of the treatment modalities seems to be similar following both the techniques implying patient's preference for complete long-term cure of symptoms and possibly less concern for minor complications. So, RBL can be adopted as the choice of treatment for grade II haemorrhoids with similar results but with out the side effects of EH while reserving EH for grade III haemorrhoids or recurrence after RBL. More robust study is required to make definitive conclusions.

摘要

背景

痔疮的传统治疗方法大致可分为两大类:侵入性较小的技术,如橡皮圈套扎术(RBL),往往产生的疼痛最小;以及更为激进的技术,如痔切除术(EH),其本质上疼痛更剧烈。几十年来,痔疮治疗领域的创新主要集中在改进传统方法,以实现微创、疼痛较轻且效果更持久的手术。新技术的出现重新引发了关于痔疮传统治疗选择作用的争论。

目的

回顾痔疮治疗中两种最常用的传统方法——橡皮圈套扎术和痔切除术的疗效及安全性。

检索策略

我们检索了所有主要的电子数据库(MEDLINE、EMBASE、CENTRAL、CINAHL)。

入选标准

纳入比较橡皮圈套扎术与痔切除术治疗成年有症状痔疮患者的随机对照试验。

数据收集与分析

我们将数据提取到预先设计的数据提取表中。二分数据以相对风险和95%置信区间呈现,连续结果以加权均数差和95%置信区间呈现。

主要结果

三项(方法学质量较差)试验符合纳入标准。痔切除术治疗后痔疮症状完全缓解情况更好(三项研究,202例患者,RR 1.68,95%CI 1.00至2.83)。研究间存在显著异质性(I² = 90.5%;P = 0.0001)。基于痔疮分级的类似分析显示,对于III度痔疮(脱垂需手法复位),痔切除术优于橡皮圈套扎术(两项试验,116例患者,RR 1.23,CI 1.04至1.45;P = 0.01)。然而,对于II度痔疮(用力停止后脱垂自行回纳)未观察到显著差异(一项试验,32例患者,RR 1.07,CI 0.94至1.21;P = 0.32)。痔切除术后需要再次治疗的患者较少(三项试验,RR 0.20,CI 0.09至0.40;P < 0.00001)。接受痔切除术的患者术后疼痛风险显著更高(三项试验,固定效应;212例患者,RR 1.94,95%CI 1.62至2.33,P < 0.00001)。两种干预措施的总体延迟并发症发生率存在显著差异(P = 0.03)(三项试验,204例患者,RR 6.32,CI 1.15至34.89)。

作者结论

本系统评价证实,与侵入性较小的橡皮圈套扎术相比,痔切除术至少对III度痔疮具有长期疗效,但代价是疼痛增加、并发症增多以及误工时间延长。然而,尽管痔切除术有这些缺点,但两种技术后患者满意度和对治疗方式的接受度似乎相似,表示患者更倾向于症状的完全长期治愈,可能对轻微并发症不太在意。因此,II度痔疮可选择橡皮圈套扎术,其效果相似但无痔切除术的副作用,而III度痔疮或橡皮圈套扎术后复发则保留痔切除术。需要更有力的研究才能得出明确结论。

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