来自软珊瑚伞花异柳珊瑚的细胞毒性异株二萜类化合物。

Cytotoxic xenia diterpenoids from the soft coral Xenia umbellata.

作者信息

El-Gamal Ali A H, Wang Shang-Kwei, Duh Chang-Yih

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

出版信息

J Nat Prod. 2006 Mar;69(3):338-41. doi: 10.1021/np058093r.

DOI:10.1021/np058093r

PMID:16562830

Abstract

Eleven new xenia diterpenoids, umbellacins A-G (1-7), 14,15-epoxy-xeniolide H (8), 3-acetyl-14,15-epoxy-xeniolide H (9), and umbellacins H and I (10, 11), were isolated from a methylene chloride-soluble fraction of the soft coral Xenia umbellata. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

摘要

从软珊瑚伞花异柳珊瑚的二氯甲烷可溶部分中分离出11种新的异株克生二萜类化合物，即伞花素A - G（1 - 7）、14,15 - 环氧 - 异柳珊瑚内酯H（8）、3 - 乙酰基 - 14,15 - 环氧 - 异柳珊瑚内酯H（9）以及伞花素H和I（10, 11）。通过广泛的光谱分析阐明了其结构，并在体外测定了它们对选定癌细胞的细胞毒性。