Hiltunen A J, Järbe T U
University of Uppsala, Department of Psychology, Sweden.
Psychopharmacology (Berl). 1992;107(4):511-6. doi: 10.1007/BF02245264.
The relationship between tolerance to ethanol and acute tolerance to ethanol was examined. One group of rats was given 1.8 g/kg ethanol, and another group was administered 18 ml/kg saline for 26 days after sessions. Animals responded under a fixed ratio ten (FR-10) schedule of food reinforcement. Thereafter, various doses of ethanol (1.3-2.5 g/kg) were examined to assess the influence of the ethanol treatment on the expression of acute tolerance. Acute tolerance was assessed by comparing the performance at equal concentrations of ethanol on the ascending and the descending limbs of the ethanol concentration curve. This was achieved by varying the time between behavioural tests since ethanol administration. Ethanol concentrations were estimated using a rebreathed air procedure. Equal concentrations of ethanol were achieved with doses of i) 1.3 g/kg (10 min post-injection, PI), and 1.8 g/kg (60 min PI), as well as with doses of ii) 2.0 g/kg (10 min PI), and 2.5 g/kg (60 min PI). Acute tolerance was demonstrated for the initially ethanol naive animals. For the animals given ethanol chronically, only doses of ethanol higher than the chronically administered dose produced evidence for acute tolerance. When the chronically dosed animals had been off ethanol for 67 days, there was evidence for acute tolerance. The present data add to the generality of the acute ethanol tolerance phenomenon, and emphasize both the appearance as well as the loss of tolerance for this effect.
研究了乙醇耐受性与乙醇急性耐受性之间的关系。一组大鼠给予1.8 g/kg乙醇，另一组在实验后26天给予18 ml/kg生理盐水。动物在固定比率十（FR-10）的食物强化时间表下做出反应。此后，检测了各种剂量的乙醇（1.3 - 2.5 g/kg），以评估乙醇处理对急性耐受性表达的影响。通过比较乙醇浓度曲线上升和下降支上相同乙醇浓度时的表现来评估急性耐受性。这是通过改变乙醇给药后行为测试之间的时间来实现的。使用再呼吸空气程序估计乙醇浓度。通过以下剂量可达到相同浓度的乙醇：i）1.3 g/kg（注射后10分钟，PI）和1.8 g/kg（注射后60分钟，PI），以及ii）2.0 g/kg（注射后10分钟，PI）和2.5 g/kg（注射后60分钟，PI）。最初未接触过乙醇的动物表现出急性耐受性。对于长期给予乙醇的动物，只有高于长期给药剂量的乙醇剂量才产生急性耐受性的证据。当长期给药的动物停止摄入乙醇67天后，有急性耐受性的证据。目前的数据增加了急性乙醇耐受性现象的普遍性，并强调了这种效应的耐受性的出现以及丧失。
