Plowman S J, Hancock J F
Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia.
Biochim Biophys Acta. 2005 Dec 30;1746(3):274-83. doi: 10.1016/j.bbamcr.2005.06.004. Epub 2005 Jun 27.
Ras proteins are compartmentalized by dynamic interactions with both plasma membrane microdomains and intracellular membranes. The mechanisms underlying Ras compartmentalization involve a series of protein/lipid, lipid/lipid and cytoskeleton interactions, resulting in the generation of discrete microdomains from which Ras operates. Segregation of Ras proteins to these different platforms regulates the formation of Ras signaling complexes and the generation of discrete signal outputs. This temporal and spatial modulation of Ras signal transduction provides a mechanism for the generation of different biological outcomes from different Ras isoforms, as well as flexibility in the signal output from a single activated isoform.
Ras蛋白通过与质膜微结构域和细胞内膜的动态相互作用而被分隔。Ras分隔的潜在机制涉及一系列蛋白质/脂质、脂质/脂质和细胞骨架相互作用，从而产生Ras发挥作用的离散微结构域。Ras蛋白向这些不同平台的分离调节了Ras信号复合物的形成以及离散信号输出的产生。Ras信号转导的这种时空调节为不同Ras亚型产生不同生物学结果提供了一种机制，同时也为单个激活亚型的信号输出提供了灵活性。
