Muthusamy Babylakshmi, Hanumanthu G, Suresh Shubha, Rekha B, Srinivas D, Karthick L, Vrushabendra B M, Sharma Salil, Mishra Goparani, Chatterjee Pritam, Mangala K S, Shivashankar H N, Chandrika K N, Deshpande Nandan, Suresh M, Kannabiran N, Niranjan Vidya, Nalli Anuradha, Prasad T S Keshava, Arun K S, Reddy Raghunath, Chandran Sreenath, Jadhav Trafina, Julie D, Mahesh M, John S Lynate, Palvankar Kshitish, Sudhir D, Bala P, Rashmi N S, Vishnupriya G, Dhar Kaushik, Reshma S, Chaerkady Raghothama, Gandhi T K B, Harsha H C, Mohan S Sujatha, Deshpande Krishna S, Sarker Malabika, Pandey Akhilesh
Institute of Bioinformatics, Bangalore, India.
Proteomics. 2005 Aug;5(13):3531-6. doi: 10.1002/pmic.200401335.
Plasma is one of the best studied compartments in the human body and serves as an ideal body fluid for the diagnosis of diseases. This report provides a detailed functional annotation of all the plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on proteins previously published in the literature as plasma proteins and the identification of multiple peptides from proteins under HUPO's Plasma Proteome Project. Our analysis revealed that 51% of these genes encoded more than one protein isoform. All single nucleotide polymorphisms involving protein-coding regions were mapped onto the protein sequences. We found a number of examples of isoform-specific subcellular localization as well as tissue expression. This database is an attempt at comprehensive annotation of a complex subproteome and is available on the web at http://www.plasmaproteomedatabase.org.
血浆是人体中研究最为深入的组分之一，是用于疾病诊断的理想体液。本报告提供了迄今为止已鉴定出的所有血浆蛋白的详细功能注释。基于先前文献中作为血浆蛋白发表的蛋白质以及人类蛋白质组组织（HUPO）血浆蛋白质组计划中蛋白质的多个肽段鉴定结果，总共对3778个不同基因编码的基因产物进行了注释。我们的分析表明，这些基因中有51%编码不止一种蛋白质异构体。所有涉及蛋白质编码区的单核苷酸多态性都被定位到蛋白质序列上。我们发现了许多异构体特异性亚细胞定位以及组织表达的例子。该数据库是对一个复杂亚蛋白质组进行全面注释的尝试，可在网站http://www.plasmaproteomedatabase.org上获取。
