Liu Ping, Yao Yu-Na, Wu Shi-De, Dong Huai-Jun, Feng Guo-Chang, Yuan Xiao-Yan
Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University, Wenhuaxilu 44, Jinan 250012, PR China.
J Inorg Biochem. 2005 Aug;99(8):1733-7. doi: 10.1016/j.jinorgbio.2005.06.002.
The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al+DE. The Al-only and Al+DE animals received injections of Al2(SO43.18H2O 600 micromol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al+DE rabbits were given deferiprone 750 micromol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al+DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration.
研究了1,2 - 二甲基 - 3 - 羟基吡啶 - 4 - 酮[去铁酮（DE）]对家兔组织和血清中铝的动员与清除的影响，以及对微量元素铜、锌和锰排泄的影响。16只新西兰家兔随机分为三组：对照组、单纯铝组和铝 + 去铁酮组。单纯铝组和铝 + 去铁酮组动物每周5天注射Al₂(SO₄)₃·18H₂O 600微摩尔铝/千克，共3周。最后一次注射铝1周后，铝 + 去铁酮组家兔每天经胃给予去铁酮750微摩尔/千克，持续2周。在第42天处死动物，取出器官并进行消化。从耳动脉采集血液3次（实验开始时、给予去铁酮前后）。采用原子吸收分光光度法测定铝以及铜、锌、锰的含量。我们的结果表明，去铁酮能大量动员组织中的铝储备。实验结束时，铝 + 去铁酮组家兔骨骼、肾脏、肝脏和大脑中的铝含量显著低于单纯铝组家兔。铜、锌、锰的含量不受去铁酮给药的影响。
