Smith J E
Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK.
Br J Sports Med. 2005 Aug;39(8):503-7; discussion 507. doi: 10.1136/bjsm.2004.013466.
To review the different methods of reducing body core temperature in patients with exertional heatstroke.
The search strategy included articles from 1966 to July 2003 using the databases Medline and Premedline, Embase, Evidence Based Medicine (EBM) reviews, SPORTDiscus, and cross referencing the bibliographies of relevant papers. Studies were included if they contained original data on cooling times or cooling rates in patients with heat illness or normal subjects who were subjected to heat stress.
In total, 17 papers were included in the analysis. From the evidence currently available, the most effective method of reducing body core temperature appears to be immersion in iced water, although the practicalities of this treatment may limit its use. Other methods include both evaporative and invasive techniques, and the use of chemical agents such as dantrolene.
The main predictor of outcome in exertional heatstroke is the duration and degree of hyperthermia. Where possible, patients should be cooled using iced water immersion, but, if this is not possible, a combination of other techniques may be used to facilitate rapid cooling. There is no evidence to support the use of dantrolene in these patients. Further work should include a randomised trial comparing immersion and evaporative therapy in heatstroke patients.
回顾降低劳力性热射病患者体核温度的不同方法。
检索策略包括使用Medline、Premedline、Embase、循证医学(EBM)综述、SPORTDiscus数据库检索1966年至2003年7月的文章,并交叉引用相关论文的参考文献。如果研究包含热疾病患者或受热应激的正常受试者的冷却时间或冷却速率的原始数据,则纳入研究。
分析共纳入17篇论文。根据目前可得的证据,降低体核温度最有效的方法似乎是浸入冰水中,尽管这种治疗方法的实际应用可能会限制其使用。其他方法包括蒸发和侵入性技术,以及使用如丹曲林等化学药物。
劳力性热射病预后的主要预测因素是体温过高的持续时间和程度。在可能的情况下,应使用冰水浸泡使患者降温,但如果无法做到这一点,可以使用其他技术组合来促进快速降温。没有证据支持在这些患者中使用丹曲林。进一步的工作应包括一项比较热射病患者浸泡疗法和蒸发疗法的随机试验。