一种具有2'-O-(2-氰基乙氧基甲基)保护基团的新型RNA合成方法。
A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group.
作者信息
Ohgi Tadaaki, Masutomi Yutaka, Ishiyama Kouichi, Kitagawa Hidetoshi, Shiba Yoshinobu, Yano Junichi
机构信息
Discovery Research Laboratories, Nippon Shinyaku Co. Ltd., 3-14-1 Sakura, Tsukuba City, Ibaraki 305-0003, Japan.
出版信息
Org Lett. 2005 Aug 4;7(16):3477-80. doi: 10.1021/ol051151f.
PMID:16048321
Abstract
A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2'-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis. [structure: see text]
摘要
已经开发出一种以2-氰基乙氧基甲基（CEM）作为2'-羟基保护基团来合成RNA寡聚物的新方法。该新方法能够合成寡核糖核苷酸，其效率和最终纯度与DNA合成中获得的相当。[结构：见原文]
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