质粒介导的喹诺酮耐药决定因子QnrA的起源
Origin of plasmid-mediated quinolone resistance determinant QnrA.
作者信息
Poirel Laurent, Rodriguez-Martinez Jose-Manuel, Mammeri Hedi, Liard Alain, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3523-5. doi: 10.1128/AAC.49.8.3523-3525.2005.
Abstract
Plasmid-mediated resistance to quinolones is increasingly reported in studies of Enterobacteriaceae. Using a PCR-based strategy, a series of gram-negative species were screened for qnrA-like genes. Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene.
摘要
在肠杆菌科细菌的研究中，越来越多地报道了质粒介导的喹诺酮耐药性。采用基于聚合酶链反应（PCR）的策略，对一系列革兰氏阴性菌进行了qnrA样基因筛选。海藻希瓦氏菌是一种来自海洋和淡水的环境细菌，被确定为该基因的储存宿主。这是获得性抗生素耐药基因溯源鉴定的极少数例子之一。
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2
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Antimicrob Agents Chemother. 2005 May;49(5):2146-7. doi: 10.1128/AAC.49.5.2146-2147.2005.
3
Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.
Antimicrob Agents Chemother. 2005 May;49(5):2144-5. doi: 10.1128/AAC.49.5.2144-2145.2005.
4
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.
Antimicrob Agents Chemother. 2005 Feb;49(2):801-3. doi: 10.1128/AAC.49.2.801-803.2005.
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Plasmid-mediated quinolone resistance in isolates obtained in german intensive care units.
Antimicrob Agents Chemother. 2005 Feb;49(2):773-5. doi: 10.1128/AAC.49.2.773-775.2005.
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Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase.
Antimicrob Agents Chemother. 2005 Jan;49(1):118-25. doi: 10.1128/AAC.49.1.118-125.2005.
7
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10
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