质粒介导的喹诺酮耐药决定因子QnrA的起源
Origin of plasmid-mediated quinolone resistance determinant QnrA.
作者信息
Poirel Laurent, Rodriguez-Martinez Jose-Manuel, Mammeri Hedi, Liard Alain, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3523-5. doi: 10.1128/AAC.49.8.3523-3525.2005.
Abstract
Plasmid-mediated resistance to quinolones is increasingly reported in studies of Enterobacteriaceae. Using a PCR-based strategy, a series of gram-negative species were screened for qnrA-like genes. Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene.
摘要
在肠杆菌科细菌的研究中，越来越多地报道了质粒介导的喹诺酮耐药性。采用基于聚合酶链反应（PCR）的策略，对一系列革兰氏阴性菌进行了qnrA样基因筛选。海藻希瓦氏菌是一种来自海洋和淡水的环境细菌，被确定为该基因的储存宿主。这是获得性抗生素耐药基因溯源鉴定的极少数例子之一。
相似文献
1
Origin of plasmid-mediated quinolone resistance determinant QnrA.质粒介导的喹诺酮耐药决定因子QnrA的起源
Antimicrob Agents Chemother. 2005 Aug;49(8):3523-5. doi: 10.1128/AAC.49.8.3523-3525.2005.
2
Prevalence and expression of the plasmid-mediated quinolone resistance determinant qnrA1.质粒介导的喹诺酮耐药决定因子qnrA1的流行情况与表达
Antimicrob Agents Chemother. 2007 Nov;51(11):4105-10. doi: 10.1128/AAC.00616-07. Epub 2007 Aug 27.
3
Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae.肠杆菌科细菌中质粒介导的喹诺酮耐药性的出现。
J Antimicrob Chemother. 2005 Sep;56(3):463-9. doi: 10.1093/jac/dki245. Epub 2005 Jul 14.
4
Investigation of plasmid-mediated quinolone resistance among isolates obtained in a Turkish intensive care unit.对土耳其一家重症监护病房分离菌株中质粒介导的喹诺酮耐药性的调查。
Jpn J Infect Dis. 2008 Jul;61(4):310-2.
5
Broad dissemination of plasmid-mediated quinolone resistance genes in sediments of two urban coastal wetlands.两种城市滨海湿地沉积物中质粒介导喹诺酮耐药基因的广泛传播。
Environ Sci Technol. 2011 Jan 15;45(2):447-54. doi: 10.1021/es1029206. Epub 2010 Dec 8.
6
Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe.欧洲大肠杆菌中质粒介导的喹诺酮耐药性的出现。
Antimicrob Agents Chemother. 2005 Jan;49(1):71-6. doi: 10.1128/AAC.49.1.71-76.2005.
7
Vibrionaceae as a possible source of Qnr-like quinolone resistance determinants.弧菌科作为喹诺酮耐药决定因子Qnr样物质的可能来源。
J Antimicrob Chemother. 2005 Dec;56(6):1118-21. doi: 10.1093/jac/dki371. Epub 2005 Oct 14.
8
Broader distribution of plasmid-mediated quinolone resistance in the United States.美国质粒介导喹诺酮耐药性的更广泛传播。
Antimicrob Agents Chemother. 2005 Jul;49(7):3001-3. doi: 10.1128/AAC.49.7.3001-3003.2005.
9
High prevalence of the plasmid-mediated quinolone resistance determinant qnrA in multidrug-resistant Enterobacteriaceae from blood cultures in Liverpool, UK.英国利物浦血培养中多重耐药肠杆菌科细菌中质粒介导的喹诺酮耐药决定子qnrA的高流行率
J Antimicrob Chemother. 2005 Dec;56(6):1115-7. doi: 10.1093/jac/dki388. Epub 2005 Oct 31.
10
qnrA prevalence in extended-spectrum beta-lactamase-positive Enterobacteriaceae isolates from Turkey.土耳其产超广谱β-内酰胺酶的肠杆菌科分离株中qnrA的流行情况。
Jpn J Infect Dis. 2008 Jan;61(1):13-7.
引用本文的文献
1
Stakeholder views on the implementation of the UK's Antimicrobial Resistance (AMR) National Action Plan (2019-2024) in relation to AMR in the environment.利益相关者对英国《抗菌药物耐药性（AMR）国家行动计划（2019 - 2024年）》在环境中抗菌药物耐药性方面实施情况的看法。
Glob Health Action. 2025 Dec;18(1):2543101. doi: 10.1080/16549716.2025.2543101. Epub 2025 Aug 28.
2
Molecular Characterization of Plasmid-Mediated Quinolone Resistance Genes in Multidrug-Resistant Isolated From Wastewater Generated From the Hospital Environment.从医院环境产生的废水中分离出的多重耐药菌中质粒介导喹诺酮耐药基因的分子特征分析
Environ Health Insights. 2025 Jun 22;19:11786302251342936. doi: 10.1177/11786302251342936. eCollection 2025.
3
Characterization of Antibiotic Resistance in Species: An Emerging Pathogen in Clinical and Environmental Settings.物种中抗生素耐药性的特征：临床和环境中的一种新兴病原体。
Microorganisms. 2025 May 13;13(5):1115. doi: 10.3390/microorganisms13051115.
4
Determination of Antibiotic Resistance Genes in the Interior Bay of Puno-Peru, Lake Titicaca.秘鲁的的的喀喀湖普诺内湾抗生素抗性基因的测定
Scientifica (Cairo). 2025 Mar 21;2025:5571355. doi: 10.1155/sci5/5571355. eCollection 2025.
5
CARPDM: cost-effective antibiotic resistome profiling of metagenomic samples using targeted enrichment.CARPDM：使用靶向富集技术对宏基因组样本进行具有成本效益的抗生素耐药基因组分析。
Appl Environ Microbiol. 2025 Mar 19;91(3):e0187624. doi: 10.1128/aem.01876-24. Epub 2025 Feb 28.
6
Antimicrobial susceptibility profile and molecular characterization of strains isolated from imported shrimps.进口对虾中分离株的抗菌药敏谱和分子特征。
Microbiol Spectr. 2024 Jul 2;12(7):e0017524. doi: 10.1128/spectrum.00175-24. Epub 2024 Jun 4.
7
Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential.隐秘环境接合质粒招募新型杂合转座子，导致具有更高分散潜力的新型质粒。
mSphere. 2024 Jun 25;9(6):e0025224. doi: 10.1128/msphere.00252-24. Epub 2024 May 21.
8
Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in spp.新型 Qnr 家族作为 spp. 中保守且固有喹诺酮类耐药决定因素
J Microbiol Biotechnol. 2024 Jun 28;34(6):1276-1286. doi: 10.4014/jmb.2403.03043. Epub 2024 Apr 19.
9
Development of an biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota.开发一种用于研究氟喹诺酮类药物对下水道生物膜微生物群影响的生物膜模型。
Front Microbiol. 2024 Mar 27;15:1377047. doi: 10.3389/fmicb.2024.1377047. eCollection 2024.
10
Fluoroquinolone resistance in complicated urinary tract infections: association with the increased occurrence and diversity of of clonal complex 131, together with ST1193.氟喹诺酮类耐药性在复杂性尿路感染中的作用：与克隆群 131 及其 ST1193 的发生率和多样性增加有关。
Front Cell Infect Microbiol. 2024 Feb 27;14:1351618. doi: 10.3389/fcimb.2024.1351618. eCollection 2024.
本文引用的文献
1
Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1.质粒介导的喹诺酮耐药性与超广谱β-内酰胺酶VEB-1的关联。
Antimicrob Agents Chemother. 2005 Jul;49(7):3091-4. doi: 10.1128/AAC.49.7.3091-3094.2005.
2
Further identification of plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Turkey.土耳其肠杆菌科细菌中质粒介导喹诺酮耐药决定子的进一步鉴定
Antimicrob Agents Chemother. 2005 May;49(5):2146-7. doi: 10.1128/AAC.49.5.2146-2147.2005.
3
Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.副溶血性弧菌染色体qnr同源物VPA0095：通过用突变基因转化证明其在大肠杆菌中降低喹诺酮敏感性的潜力。
Antimicrob Agents Chemother. 2005 May;49(5):2144-5. doi: 10.1128/AAC.49.5.2144-2145.2005.
4
Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b.从福氏志贺菌2b型的一个可转移质粒中克隆一种新型喹诺酮耐药基因。
Antimicrob Agents Chemother. 2005 Feb;49(2):801-3. doi: 10.1128/AAC.49.2.801-803.2005.
5
Plasmid-mediated quinolone resistance in isolates obtained in german intensive care units.德国重症监护病房分离株中质粒介导的喹诺酮耐药性
Antimicrob Agents Chemother. 2005 Feb;49(2):773-5. doi: 10.1128/AAC.49.2.773-775.2005.
6
Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase.质粒编码的喹诺酮耐药蛋白Qnr与大肠杆菌DNA促旋酶的相互作用。
Antimicrob Agents Chemother. 2005 Jan;49(1):118-25. doi: 10.1128/AAC.49.1.118-125.2005.
7
Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe.欧洲大肠杆菌中质粒介导的喹诺酮耐药性的出现。
Antimicrob Agents Chemother. 2005 Jan;49(1):71-6. doi: 10.1128/AAC.49.1.71-76.2005.
8
Stability of fluoroquinolone antibiotics in river water samples and in octadecyl silica solid-phase extraction cartridges.氟喹诺酮类抗生素在河水样品及十八烷基硅胶固相萃取柱中的稳定性。
Anal Bioanal Chem. 2004 Sep;380(1):123-8. doi: 10.1007/s00216-004-2730-y. Epub 2004 Jul 28.
9
Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae.来自海藻希瓦氏菌的一种染色体编码的碳青霉烯水解性安布勒D类β-内酰胺酶的遗传和生化特性分析
Antimicrob Agents Chemother. 2004 May;48(5):1670-5. doi: 10.1128/AAC.48.5.1670-1675.2004.
10
Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organisms.1989 - 2000年住院患者和门诊患者肠杆菌科分离株中氟喹诺酮耐药性的纵向趋势：不同微生物耐药性出现情况及流行病学差异
Clin Infect Dis. 2004 Mar 1;38(5):655-62. doi: 10.1086/381549. Epub 2004 Feb 17.
Zotero 插件