质粒介导的喹诺酮耐药性与超广谱β-内酰胺酶VEB-1的关联。
Association of plasmid-mediated quinolone resistance with extended-spectrum beta-lactamase VEB-1.
作者信息
Poirel Laurent, Van De Loo Marc, Mammeri Hedi, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3091-4. doi: 10.1128/AAC.49.7.3091-3094.2005.
Abstract
Association of the plasmid-mediated quinolone resistance determinant QnrA and the bla(VEB-1) gene was identified in a single Enterobacter cloacae isolate from K.-Bicêtre, France, and in 11 out of 23 bla(VEB-1)-positive enterobacterial isolates from Bangkok, Thailand. This result may explain in part the association between quinolone and extended-spectrum beta-lactam resistance.
摘要
在法国克比塞特市分离出的一株阴沟肠杆菌中，以及在泰国曼谷23株携带bla(VEB-1)基因的肠杆菌分离株中的11株中，发现了质粒介导的喹诺酮耐药决定簇QnrA与bla(VEB-1)基因的关联。这一结果可能部分解释了喹诺酮耐药与超广谱β-内酰胺耐药之间的关联。
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