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在肠杆菌质粒中形成多抗性位点的与IS26相关的In4型整合子。

IS26-associated In4-type integrons forming multiresistance loci in enterobacterial plasmids.

作者信息

Miriagou Vivi, Carattoli Alessandra, Tzelepi Eva, Villa Laura, Tzouvelekis Leonidas S

机构信息

Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11521, Greece.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3541-3. doi: 10.1128/AAC.49.8.3541-3543.2005.

DOI:10.1128/AAC.49.8.3541-3543.2005
PMID:16048979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196216/
Abstract

Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.

摘要

来自肠杆菌质粒的三个不同的多抗性基因座均包含一个整合子和一个与IS26相关的序列。序列比较表明，其具有一个共同的祖先结构，该结构源于IS26插入In4型整合子的5'保守区段，并通过获取基因盒以及IS26介导的多种来源的其他抗性基因的募集而进化。

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本文引用的文献

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CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.CMY-13，一种由大肠杆菌质粒编码的新型诱导型头孢菌素酶。
Antimicrob Agents Chemother. 2004 Aug;48(8):3172-4. doi: 10.1128/AAC.48.8.3172-3174.2004.
2
Evolutionary mapping of the SHV beta-lactamase and evidence for two separate IS26-dependent blaSHV mobilization events from the Klebsiella pneumoniae chromosome.SHVβ-内酰胺酶的进化图谱以及来自肺炎克雷伯菌染色体的两个独立的IS26依赖性blaSHV移动事件的证据。
J Antimicrob Chemother. 2004 Jul;54(1):69-75. doi: 10.1093/jac/dkh251. Epub 2004 May 26.
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Structure and mode of transposition of Tn2555 carrying sucrose utilization genes.携带蔗糖利用基因的Tn2555转座子的结构与转座模式。
FEMS Microbiol Lett. 2004 Apr 15;233(2):353-9. doi: 10.1016/j.femsle.2004.03.016.
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Plasmid-mediated antimicrobial resistance in Salmonella enterica.肠炎沙门氏菌中的质粒介导的抗菌耐药性。
Curr Issues Mol Biol. 2003 Oct;5(4):113-22.
5
Characterization of In111, a class 1 integron that carries the extended-spectrum beta-lactamase gene blaIBC-1.携带超广谱β-内酰胺酶基因bla IBC-1的1类整合子In111的特性分析。
FEMS Microbiol Lett. 2003 Aug 8;225(1):149-53. doi: 10.1016/S0378-1097(03)00510-X.
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Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-beta-lactamase VIM-1.携带编码金属β-内酰胺酶VIM-1的自我转移性多耐药质粒的大肠杆菌。
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