Stevens Victoria L, McCullough Marjorie L, Diver W Ryan, Rodriguez Carmen, Jacobs Eric J, Thun Michael J, Calle Eugenia E
Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329, USA.
Cancer Causes Control. 2005 Aug;16(6):643-50. doi: 10.1007/s10552-005-0384-5.
To assess the association between the use of multivitamins and prostate cancer mortality.
A total of 5585 deaths from prostate cancer were identified during 18 years of follow-up of 475,726 men who were cancer-free and provided complete information on multivitamin use at enrollment in the Cancer Prevention Study II (CPS-II) cohort in 1982. Cox proportional hazards modeling was used to measure the association between multivitamin use at baseline and death from prostate cancer and to adjust for potential confounders.
The death rate from prostate cancer was marginally higher among men who took multivitamins regularly (> or =15 times/month) compared to non-users (multivariate rate ratio=1.07, 95% CI: 0.99-1.15); this risk was statistically significant only for those multivitamin users who used no additional (vitamin A, C, or E) supplements (multivariate rate ratio=1.15, 95% CI: 1.05-1.26). In addition, risk was greatest during the initial four years of follow-up (1982-1986, multivariate rate ratio=1.12, 95 CI: 0.87-1.46).
Regular multivitamin use was associated with a small increase in prostate cancer death rates in our study, and this association was limited to a subgroup of users.
评估多种维生素的使用与前列腺癌死亡率之间的关联。
在对475726名无癌症男性进行的18年随访期间，共确定了5585例前列腺癌死亡病例。这些男性于1982年参加了癌症预防研究II（CPS-II）队列研究，入组时无癌症且提供了关于多种维生素使用的完整信息。采用Cox比例风险模型来衡量基线时多种维生素的使用与前列腺癌死亡之间的关联，并对潜在混杂因素进行校正。
与未使用者相比，定期服用多种维生素（每月≥15次）的男性前列腺癌死亡率略高（多变量率比=1.07，95%可信区间：0.99-1.15）；仅对于那些未额外补充（维生素A、C或E）的多种维生素使用者，该风险具有统计学意义（多变量率比=1.15，95%可信区间：1.05-1.26）。此外，在随访的最初四年（1982-1986年）风险最高（多变量率比=1.12，95%可信区间：0.87-1.46）。
在我们的研究中，定期使用多种维生素与前列腺癌死亡率略有增加相关，且这种关联仅限于部分使用者亚组。
