Murthy Ramesh, Honavar Santosh G, Burman Sanghamitra, Vemuganti Geeta K, Naik Milind N, Reddy Vijay Anand P
Ocular Oncology Service, LV Prasad Eye Institute, LV Prasad Marg, Hyderabad, Inda.
Ophthalmic Plast Reconstr Surg. 2005 Jul;21(4):307-9. doi: 10.1097/01.iop.0000169426.57497.24.
A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil. Eyelid-sparing orbital exenteration was performed after 3 cycles of chemotherapy, followed by radiotherapy to the regional lymph nodes. Subsequently, 3 cycles of adjuvant chemotherapy were administered. Significant eyelid and orbital tumor volume reduction was achieved with neoadjuvant chemotherapy, making eyelid-sparing orbital exenteration possible. Chemotherapy also spared the patient from radical neck dissection. The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.
一名55岁的亚洲印度女性，患有左眼下睑复发性皮脂腺癌并伴有眼眶侵犯和区域淋巴结转移，接受了以卡铂和5-氟尿嘧啶联合使用的新辅助化疗。化疗3个周期后进行了保留眼睑的眼眶内容剜除术，随后对区域淋巴结进行了放射治疗。随后，给予3个周期的辅助化疗。新辅助化疗使眼睑和眼眶肿瘤体积显著缩小，从而使保留眼睑眼眶内容剜除术成为可能。化疗还使患者免于进行根治性颈部清扫术。该患者并发症有限，在随访26个月时无局部、区域和全身疾病。
