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眼睑复发性皮脂腺癌伴眶内侵犯和区域淋巴结病的新辅助化疗。

Neoadjuvant chemotherapy in recurrent sebaceous carcinoma of eyelid with orbital invasion and regional lymphadenopathy.

机构信息

Ophthalmic Plastic surgery, Orbit and Ocular Oncology service, L.V. Prasad Eye Institute, Bhubaneswar, Orissa, India

出版信息

Ophthalmic Plast Reconstr Surg. 2010 Sep-Oct;26(5):366-8. doi: 10.1097/IOP.0b013e3181c32515.

DOI:10.1097/IOP.0b013e3181c32515
PMID:20856079
Abstract

A 35-year-old man presented with a recurrent temporal conjunctival mass (25 × 12 mm) involving about six-clock hours of the limbus in the left eye. The mass encroached onto the temporal half of cornea and showed surface keratin, large intrinsic and feeder vessels. It infiltrated the deep corneal stroma. There were no cells in the anterior chamber. Ultrasound biomicroscopy confirmed infiltration of deep corneal stroma without intraocular invasion. Surgery involved excision of the conjunctival component with 4-mm margin, lamellar sclerectomy and a penetrating sclerokeratoplasty with 3 mm of healthy corneal margin. Cryotherapy (double-freeze-thaw) was done to the conjunctival margins. Histopathology showed it to be invasive sebaceous cell carcinoma. A thin layer of deep corneal stroma and all conjunctival margins were uninvolved. At thirty-six weeks after treatment the left eye recorded a visual acuity of finger counting at 1 meter distance and no recurrence.

摘要

一位 35 岁男性,左眼出现复发性颞侧球结膜肿块(25×12mm),累及约六点钟位的角膜缘。肿块侵犯至角膜颞侧的一半,并呈现表面角化、大的固有和滋养血管。它浸润了深层角膜基质。前房内没有细胞。超声生物显微镜检查证实了深层角膜基质的浸润,没有眼内侵犯。手术包括切除结膜成分,边缘为 4mm,板层巩膜切除术和穿透性巩膜角膜移植术,保留 3mm 的健康角膜缘。对结膜边缘进行冷冻治疗(双重冷冻-解冻)。组织病理学显示为侵袭性的皮脂腺癌。深层角膜基质的薄层和所有结膜边缘均未受累。治疗后 36 周,左眼记录的最佳矫正视力为 1 米处手动,无复发。

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