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[急性黄斑神经视网膜病变——病例报告]

[Acute macular neuroretinopathy--case report].

作者信息

Pojda-Wilczek Dorota, Herba Ewa

机构信息

Z Katedry i Oddziału Klinicznego Okulistyki Slaskiej Akademii Medycznej, Szpital Specjalistyczny nr 1 w Bytomiu.

出版信息

Klin Oczna. 2005;107(1-3):127-9.

Abstract

PURPOSE

The aim of this study is to present rare retinal disease of unknown origin.

MATERIAL AND METHODS

27-years-old man was diagnosed because of poor vision in the left eye, which lasted 4-5 weeks. Following examinations were performed: Visual acuity, contrast sensitivity, color perception, visual field, fluorescein angiography (AF), visual evoked potentials (VEP), full-field flash electroretinography (flash ERG), focal-foveal electroretinography (focal ERG), multifocal electroretinography (multifocal ERG). Follow-up 1.5 year.

RESULTS

Visual acuity of right eye was 1.25 (-0.1 log MAR) and left eye 1.0 (0.0 log MAR). In left eye between optic disc and macula irregular lesion with dots of retinal pigment epithelium atrophy and little edema was seen. AF revealed small "window" defects. In visual field of the left eye paracentral relative scotoma occurred and in stereokampimetry central relative scotoma was found about 5 degrees from the fixation point. In VEP latency of P100 was delayed and amplitude was reduced in both eyes. In flash as well as focal ERG small reduction of cone function and delayed implicit time of b-wave were found in left eye. In general examination no focal inflammation and no abnormalities in laboratory tests were found. The patient was treated with steroids for 3 weeks. After ten days of general steroid treatment visual acuity improved to 1.25 and subjective improvement of vision occurred. Control examination after 1.5 year revealed no patient's complains, visual acuity 1.25, no change in visual field, VEP improvement. In left eye flat irregular area with pigment epithelium atrophy was seen.

CONCLUSIONS

Acute macular neuroretinopathy may be diagnosed after detail examination. Prognosis is generally good, recovery is slow, but despite of local retinal atrophy subjective complains disappear completely.

摘要

目的

本研究旨在介绍病因不明的罕见视网膜疾病。

材料与方法

一名27岁男性因左眼视力下降4至5周而被诊断。进行了以下检查:视力、对比敏感度、色觉、视野、荧光素血管造影(AF)、视觉诱发电位(VEP)、全视野闪光视网膜电图(闪光ERG)、中心凹局部视网膜电图(局部ERG)、多焦视网膜电图(多焦ERG)。随访1.5年。

结果

右眼视力为1.25(-0.1对数最小分辨角),左眼视力为1.0(0.0对数最小分辨角)。在左眼视盘和黄斑之间可见不规则病变,伴有视网膜色素上皮萎缩点和少量水肿。AF显示小的“窗样”缺损。左眼视野出现旁中心相对暗点,在立体视野计检查中,距注视点约5度处发现中心相对暗点。双眼VEP中P100潜伏期延迟,波幅降低。在闪光ERG和局部ERG中,左眼发现视锥细胞功能略有降低,b波潜伏期延迟。一般检查未发现局部炎症,实验室检查无异常。患者接受了3周的类固醇治疗。全身类固醇治疗10天后,视力提高到1.25,视力主观改善。1.5年后的对照检查显示患者无主诉,视力为1.25,视野无变化,VEP改善。左眼可见色素上皮萎缩的扁平不规则区域。

结论

详细检查后可诊断急性黄斑神经视网膜病变。预后一般良好,恢复缓慢,但尽管存在局部视网膜萎缩,主观症状可完全消失。

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