Tally F P, Cuchural G J, Jacobus N V, Gorbach S L, Aldridge K, Cleary T, Finegold S M, Hill G, Iannini P, O'Keefe J P
Antimicrob Agents Chemother. 1985 Nov;28(5):675-7. doi: 10.1128/AAC.28.5.675.
A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the evaluation: cefamandole, cefuroxime, and cefonicid. The results for the strains tested with the original nine drugs in 1983 were compared with those for 1,292 isolates tested in 1981 and 1982. The most active beta-lactam drug was piperacillin, which had an 8% resistance rate. Cefoxitin resistance increased from 10% in 1982 to 16% in 1983. High rates of resistance to cefotaxime, cefoperazone, cefamandole, cefonicid, and cefuroxime were encountered. No metronidazole- or chloramphenicol-resistant isolates were found during the 3 years of the study. Susceptibility patterns varied at the eight hospitals: the outbreak of cefoxitin resistance reported in 1982 at New England Medical Center remitted, while a high clindamycin resistance rate was documented at one hospital in 1983. These data indicate the need for determining the susceptibility patterns for the B. fragilis group of organisms at each hospital.
1983年，新英格兰医学中心继续开展了一项针对脆弱拟杆菌群的全国性药敏调查。共从美国八个中心获取了555株菌株。除了前两年研究的九种抗菌药物外，又增加了三种药物进行评估：头孢孟多、头孢呋辛和头孢尼西。将1983年用最初九种药物检测的菌株结果与1981年和1982年检测的1292株菌株的结果进行了比较。活性最强的β-内酰胺类药物是哌拉西林，耐药率为8%。头孢西丁耐药率从1982年的10%上升至1983年的16%。头孢噻肟、头孢哌酮、头孢孟多、头孢尼西和头孢呋辛的耐药率较高。在三年的研究期间未发现耐甲硝唑或耐氯霉素的分离株。八家医院的药敏模式各不相同：1982年新英格兰医学中心报告的头孢西丁耐药暴发得到缓解，而1983年一家医院记录到较高的克林霉素耐药率。这些数据表明有必要确定每家医院脆弱拟杆菌群生物体的药敏模式。
