枯草芽孢杆菌的多药外排转运蛋白是金黄色葡萄球菌NorA蛋白的结构和功能同源物。
The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.
作者信息
Neyfakh A A
机构信息
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60680.
出版信息
Antimicrob Agents Chemother. 1992 Feb;36(2):484-5. doi: 10.1128/AAC.36.2.484.
Abstract
The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr.
摘要
枯草芽孢杆菌多药外排转运蛋白Bmr与金黄色葡萄球菌基因norA的产物具有44%的氨基酸序列同一性，norA负责临床上与氟喹诺酮类药物相关的耐药性。我们在此表明，枯草芽孢杆菌中bmr的过表达赋予了对氟喹诺酮类药物的强大抗性，而利血平（一种Bmr抑制剂）可逆转这种抗性。
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