A promising genetic approach for the treatment of epilepsy.
作者信息
Wallace Robyn
出版信息
Epilepsy Curr. 2004 Jul-Aug;4(4):164-6. doi: 10.1111/j.1535-7597.2004.44017.x.
Abstract
摘要
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Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development.重组腺相关病毒介导的甘丙肽在大鼠海马体中的表达抑制癫痫发作发展。
Eur J Neurosci. 2003 Oct;18(7):2087-92. doi: 10.1046/j.1460-9568.2003.02926.x.
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Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion.腺相关病毒载体甘丙肽表达与分泌对癫痫发作及神经元死亡的减轻作用
Nat Med. 2003 Aug;9(8):1076-80. doi: 10.1038/nm901. Epub 2003 Jul 13.
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Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.甘丙肽转基因小鼠表现出阿尔茨海默病特有的认知和神经化学缺陷。
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4184-9. doi: 10.1073/pnas.061445598. Epub 2001 Mar 20.
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Modulation of hippocampal excitability and seizures by galanin.甘丙肽对海马兴奋性和癫痫发作的调节作用。
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Patients with refractory seizures.难治性癫痫患者。
N Engl J Med. 1999 May 20;340(20):1565-70. doi: 10.1056/NEJM199905203402008.
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Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus.癫痫持续状态动物模型中甘丙肽对癫痫发作的调节作用及海马甘丙肽对癫痫发作的调节作用。
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Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus.
Eur J Pharmacol. 1993 Mar 15;245(1):1-7. doi: 10.1016/0922-4106(93)90162-3.
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