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Targeting the trunk of multi-root common epilepsy with gene therapy.

作者信息

Sheibani Mehrnaz, Minassian Berge A

机构信息

Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.

出版信息

Mol Ther Methods Clin Dev. 2025 Apr 1;33(2):101453. doi: 10.1016/j.omtm.2025.101453. eCollection 2025 Jun 12.

DOI:10.1016/j.omtm.2025.101453
PMID:40236499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999442/
Abstract
摘要

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本文引用的文献

1
State-of-the-art gene therapy in epilepsy.癫痫领域的前沿基因治疗
Curr Opin Neurol. 2025 Apr 1;38(2):128-134. doi: 10.1097/WCO.0000000000001349. Epub 2025 Feb 7.
2
A novel AAV9-dual microRNA-vector targeting in the hippocampus as a treatment for mesial temporal lobe epilepsy.一种靶向海马体的新型腺相关病毒9型双微小RNA载体,用于治疗内侧颞叶癫痫。
Mol Ther Methods Clin Dev. 2024 Sep 16;32(4):101342. doi: 10.1016/j.omtm.2024.101342. eCollection 2024 Dec 12.
3
Gene therapy for epilepsy targeting neuropeptide Y and its Y2 receptor to dentate gyrus granule cells.针对神经肽 Y 及其 Y2 受体的基因治疗靶向齿状回颗粒细胞治疗癫痫。
EMBO Rep. 2024 Oct;25(10):4387-4409. doi: 10.1038/s44319-024-00244-0. Epub 2024 Sep 9.
4
New epilepsy therapies in development.正在开发的新癫痫疗法。
Nat Rev Drug Discov. 2024 Sep;23(9):682-708. doi: 10.1038/s41573-024-00981-w. Epub 2024 Jul 22.
5
Anti-seizure gene therapy for focal cortical dysplasia.抗癫痫基因治疗局灶性皮质发育不良。
Brain. 2024 Feb 1;147(2):542-553. doi: 10.1093/brain/awad387.
6
Dynorphin-based "release on demand" gene therapy for drug-resistant temporal lobe epilepsy.基于强啡肽的“按需释放”基因治疗耐药性颞叶癫痫。
EMBO Mol Med. 2019 Oct;11(10):e9963. doi: 10.15252/emmm.201809963. Epub 2019 Sep 5.
7
Epilepsy Gene Therapy Using an Engineered Potassium Channel.癫痫的基因治疗:利用工程化钾离子通道
J Neurosci. 2019 Apr 17;39(16):3159-3169. doi: 10.1523/JNEUROSCI.1143-18.2019. Epub 2019 Feb 12.
8
Neuropeptides as targets for the development of anticonvulsant drugs.作为抗惊厥药物开发靶点的神经肽。
Mol Neurobiol. 2014 Oct;50(2):626-46. doi: 10.1007/s12035-014-8669-x. Epub 2014 Apr 6.
9
Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development.腺相关病毒载体介导的生长抑素在大鼠海马中的表达抑制癫痫发作的发展。
Neurosci Lett. 2012 Feb 16;509(2):87-91. doi: 10.1016/j.neulet.2011.12.035. Epub 2012 Jan 5.
10
A promising genetic approach for the treatment of epilepsy.一种治疗癫痫的有前景的基因方法。
Epilepsy Curr. 2004 Jul-Aug;4(4):164-6. doi: 10.1111/j.1535-7597.2004.44017.x.