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Targeting the trunk of multi-root common epilepsy with gene therapy.

作者信息

Sheibani Mehrnaz, Minassian Berge A

机构信息

Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.

出版信息

Mol Ther Methods Clin Dev. 2025 Apr 1;33(2):101453. doi: 10.1016/j.omtm.2025.101453. eCollection 2025 Jun 12.

Abstract
摘要

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本文引用的文献

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State-of-the-art gene therapy in epilepsy.
Curr Opin Neurol. 2025 Apr 1;38(2):128-134. doi: 10.1097/WCO.0000000000001349. Epub 2025 Feb 7.
2
A novel AAV9-dual microRNA-vector targeting in the hippocampus as a treatment for mesial temporal lobe epilepsy.
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Gene therapy for epilepsy targeting neuropeptide Y and its Y2 receptor to dentate gyrus granule cells.
EMBO Rep. 2024 Oct;25(10):4387-4409. doi: 10.1038/s44319-024-00244-0. Epub 2024 Sep 9.
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New epilepsy therapies in development.
Nat Rev Drug Discov. 2024 Sep;23(9):682-708. doi: 10.1038/s41573-024-00981-w. Epub 2024 Jul 22.
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Anti-seizure gene therapy for focal cortical dysplasia.
Brain. 2024 Feb 1;147(2):542-553. doi: 10.1093/brain/awad387.
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EMBO Mol Med. 2019 Oct;11(10):e9963. doi: 10.15252/emmm.201809963. Epub 2019 Sep 5.
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Epilepsy Gene Therapy Using an Engineered Potassium Channel.
J Neurosci. 2019 Apr 17;39(16):3159-3169. doi: 10.1523/JNEUROSCI.1143-18.2019. Epub 2019 Feb 12.
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Mol Neurobiol. 2014 Oct;50(2):626-46. doi: 10.1007/s12035-014-8669-x. Epub 2014 Apr 6.
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Adeno associated viral vector-mediated expression of somatostatin in rat hippocampus suppresses seizure development.
Neurosci Lett. 2012 Feb 16;509(2):87-91. doi: 10.1016/j.neulet.2011.12.035. Epub 2012 Jan 5.
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