Kuru Oktay, Sentürk Umit Kemal, Gülkesen Hakan, Demir Necdet, Gündüz Filiz
Department of Physiology, Akdeniz University, Medical Faculty, Campus 07070, Antalya, Turkey.
Ren Fail. 2005;27(4):459-63.
Nitric oxide (NO) is involved in regulation of vascular tone and renal hemodynamics. Inhibition of NO synthase (NOS) by Nomega-nitro-L-arginine methyl ester (L-NAME) promotes systemic hypertension and glomerular damage. Exercise is effective in reducing elevated blood pressure in hypertensive individuals and rats treated with L-NAME. We investigated the effects of regular aerobic exercise on renal injury in hypertensive rats with NOS inhibition. Adult Wistar rats were divided into four groups: sedentary or exercising, nonhypertensive (two groups) and hypertensive, sedentary or exercising (two groups). Treadmill running exercise was prolonged for 4 weeks (60 min.day(-1), 5 days/week, 20 m.min(-1), no incline), and hypertension was induced by L-NAME given orally to rats for 4 weeks (25 mg.kg(-1).day(-1) in drinking water). Blood pressure was monitored at baseline and then once a week throughout L-NAME administration. Kidney sections were examined for renal histopathology. Hypertensive animals exhibited elevated blood pressure, and exercise partly prevented this elevation. Renal injury observed as arteriolar wall thickening, focal tubular atrophy, and interstitial inflammatory infiltration was apparent in hypertensive animals, and exercise induced further renal damage in hypertensive animals. The present training protocol exacerbates renal insufficiency in NOS-blockage hypertension in rats.
一氧化氮（NO）参与血管张力和肾血流动力学的调节。Nω-硝基-L-精氨酸甲酯（L-NAME）抑制一氧化氮合酶（NOS）会导致系统性高血压和肾小球损伤。运动对于降低高血压个体以及接受L-NAME治疗的大鼠的血压升高有效。我们研究了规律有氧运动对NOS抑制型高血压大鼠肾损伤的影响。成年Wistar大鼠被分为四组：久坐或运动的非高血压组（两组）以及久坐或运动的高血压组（两组）。跑步机跑步运动持续4周（60分钟/天，每周5天，20米/分钟，无坡度），通过给大鼠口服L-NAME 4周（饮用水中25毫克/千克/天）诱导高血压。在基线时监测血压，然后在整个L-NAME给药期间每周监测一次。检查肾脏切片的肾脏组织病理学。高血压动物表现出血压升高，运动部分预防了这种升高。在高血压动物中观察到的肾损伤表现为小动脉壁增厚、局灶性肾小管萎缩和间质炎症浸润，而运动在高血压动物中诱导了进一步的肾损伤。目前的训练方案加剧了大鼠NOS阻断型高血压中的肾功能不全。
