Bundgaard T, Sørensen F B, Gaihede M, Søgaard H, Overgaard J
Department of Otolaryngology, Aarhus University Hospital, Denmark.
Cancer. 1992 Jul 1;70(1):1-13. doi: 10.1002/1097-0142(19920701)70:1<1::aid-cncr2820700102>3.0.co;2-s.
A consecutive series of all 78 incident cases of intraoral squamous cell carcinoma occurring during a 2-year period in a population of 1.4 million inhabitants were evaluated by histologic score (the modified classification of Jacobsson et al.), flow cytometry, stereology, tumor size, and the TNM classification.
The investigation showed a significant difference between the volume-weighted mean nuclear volume (nuclear vv) of oral leukoplakia (n = 29) and oral squamous cell carcinomas (P = 0.001). The value of the parameters as prognostic indicators of survival and recurrence was tested with Kaplan-Meier plots and Cox multiple hazard regression analysis. Tumor size, T-stage, stereologically estimated nuclear vv, and mean nuclear profile area were all of significant prognostic value in single factor analysis with reference to both survival and recurrence. The histologic parameters of mitotic activity, morphologic nuclear dedifferentiation, and histologic mean malignancy score and the DNA ploidy level had no prognostic value. A prognostic index based on the results of the Cox analysis that included T-stage and nuclear vv was correlated highly with survival (P = 0.00001) and recurrence (P = 0.002).
These findings may contribute to optimal and individualized therapy.
对在一个140万人口中两年内发生的78例口腔鳞状细胞癌新发病例进行了连续研究，通过组织学评分（雅各布松等人的改良分类法）、流式细胞术、体视学、肿瘤大小和TNM分类进行评估。
研究显示口腔白斑（n = 29）与口腔鳞状细胞癌的体积加权平均核体积（核vv）之间存在显著差异（P = 0.001）。使用Kaplan-Meier曲线和Cox多因素风险回归分析对这些参数作为生存和复发预后指标的价值进行了测试。在单因素分析中，就生存和复发而言，肿瘤大小、T分期、体视学估计的核vv和平均核轮廓面积均具有显著的预后价值。有丝分裂活性、形态学核去分化、组织学平均恶性度评分和DNA倍体水平等组织学参数无预后价值。基于Cox分析结果的一个包含T分期和核vv的预后指数与生存（P = 0.00001）和复发（P = 0.002）高度相关。
这些发现可能有助于实现最佳的个体化治疗。
