Mattes R D, Curran W J, Alavi J, Powlis W, Whittington R
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308.
Cancer. 1992 Jul 1;70(1):192-200. doi: 10.1002/1097-0142(19920701)70:1<192::aid-cncr2820700130>3.0.co;2-g.
The nutritional implications of learned food aversions were evaluated in patients with newly diagnosed cancer receiving either chemotherapy (n = 53) or radiation therapy (n = 49).
Aversion incidence was determined by questionnaires and a food challenge. Measures of dietary and nutritional status included ratings of appetite and chemosensory function; reported shifts of food selection and measured body weight; lymphocyte count; hematocrit; and plasma albumin, transferrin, and hemoglobin levels. Quality of life was assessed by self-ratings of mood and well-being.
Subsequent to the initiation of treatments, aversions formed in 56% and 62% of patients receiving chemotherapy and radiation therapy, respectively. The aversions were specific (two to four items per afflicted patient) and transient (mean duration, 0.25-2 months). All types of foods and beverages were targeted. No significant association was observed between food aversion incidence and any measure of dietary complications, nutritional status, or quality of life.
Although food aversions are a common sequela of chemotherapy and radiation therapy, they generally have limited clinical significance.
对新诊断为癌症且正在接受化疗（n = 53）或放疗（n = 49）的患者评估习得性食物厌恶的营养影响。
通过问卷调查和食物激发试验确定厌恶发生率。饮食和营养状况的测量指标包括食欲和化学感觉功能评分；报告的食物选择变化和测量的体重；淋巴细胞计数；血细胞比容；以及血浆白蛋白、转铁蛋白和血红蛋白水平。生活质量通过情绪和幸福感的自我评分进行评估。
治疗开始后，接受化疗和放疗的患者中分别有56%和62%形成了厌恶。这些厌恶是特定的（每位患病患者有两到四项）且是短暂的（平均持续时间为0.25 - 2个月）。所有类型的食物和饮料都成为目标。未观察到食物厌恶发生率与任何饮食并发症、营养状况或生活质量指标之间存在显著关联。
尽管食物厌恶是化疗和放疗的常见后遗症，但它们通常临床意义有限。
